Crude extract of cyanobacterium Radiocystis fernandoi strain R28 induces anemia and oxidative stress in fish erythrocytes

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dc.creatorMarise Margareth Sakuragui
dc.creatorMarisa Narciso Fernandes
dc.creatorMarcelo Gustavo Paulino
dc.creatorNaiara Elisabete da Silva e Souza
dc.creatorDriele Tavares
dc.creatorAna Paula Terezan
dc.creatorEmanuele Pesenti
dc.creatorAlessandra Giani
dc.creatorJoão Batista Fernandes
dc.creatorMarta Margarete Cestari
dc.date.accessioned2023-07-14T19:15:07Z
dc.date.accessioned2025-09-09T01:12:15Z
dc.date.available2023-07-14T19:15:07Z
dc.date.issued2019
dc.identifier.doihttps://doi.org/10.1016/j.toxicon.2019.08.002
dc.identifier.issn1879-3150
dc.identifier.urihttps://hdl.handle.net/1843/56245
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofToxicon
dc.rightsAcesso Aberto
dc.subjectEnzimas
dc.subjectCianobacteria
dc.subjectHematologia
dc.subject.otherAntioxidant enzymes
dc.subject.otherGenotoxicity
dc.subject.otherHematology
dc.subject.otherLipid peroxidation
dc.subject.otherMicrocystins
dc.titleCrude extract of cyanobacterium Radiocystis fernandoi strain R28 induces anemia and oxidative stress in fish erythrocytes
dc.typeArtigo de periódico
local.citation.epage24
local.citation.spage18
local.citation.volume169
local.description.resumoThe cyanobacterium Radiocystis fernandoi has been frequently identified in cyanobacterial blooms in Brazil. Recently, R. fernandoi strain R28, which produces microcystin (MC)-RR and MC-YR, was isolated from the Furnas reservoir, Minas Gerais, Brazil. The present study evaluated the hematological variables and erythrocyte antioxidant responses, lipid peroxidation (LPO), and genotoxicity in a neotropical fish (Hoplias malabaricus) after acute and subchronic exposure to a crude extract (CE) of R. fernandoi strain R28. Acute exposure (12 or 96 h) consisted of a single intraperitoneal (i.p.) CE injection, and subchronic exposure consisted of one i.p. CE injection every 72 h for 30 days. After acute exposure, fish exhibited macrocytic anemia (12 h post-injection) followed by normocytic anemia (96 h post-injection). The increased activity of superoxide dismutase, glutathione peroxidase, glutathione-S-transferase, and the glutathione level in the erythrocytes did not prevent oxidative stress, manifested as lipid peroxidation and elevated DNA damage after acute exposure. After subchronic exposure, the hematological variables recovered, and the absence of erythrocyte oxidative stress suggests possible modulation by other biological factors, including a possible decrease in MC uptake by the cells and/or increasing detoxification efficiency that precludes erythrocyte damage.
local.identifier.orcidhttps://orcid.org/0000-0001-9621-5695
local.identifier.orcidhttps://orcid.org/0000-0003-0464-6848
local.identifier.orcidhttps://orcid.org/0000-0002-6864-887X
local.identifier.orcidhttps://orcid.org/0000-0002-9515-1930
local.identifier.orcidhttps://orcid.org/0000-0002-2524-8534
local.identifier.orcidhttps://orcid.org/0000-0002-2924-3327
local.identifier.orcidhttps://orcid.org/0000-0001-6064-966X
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE BOTÂNICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0041010119304258

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