Evaluation of antitumor activity of long-circulating and ph-sensitive liposomes containing ursolic acid in animal models of breast tumor and gliosarcoma.

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dc.creatorTalita Guieiro Ribeiro Rocha
dc.creatorSávia Caldeira de Araújo Lopes
dc.creatorGeovani Dantas Cassali
dc.creatorÊnio Ferreira
dc.creatorEmerson Soares Veloso
dc.creatorGeovanni Dantas Cassali
dc.creatorEnio Ferreira
dc.creatorEmerson Soares Veloso
dc.creatorElaine Amaral Leite
dc.creatorFernão Castro Braga
dc.creatorLucas Antônio Miranda Ferreira
dc.creatorDaniel Balvay
dc.creatorAnikitos Garofalakis
dc.creatorMônica Cristina Oliveira
dc.creatorBertrand Tavitian
dc.date.accessioned2023-03-13T18:10:48Z
dc.date.accessioned2025-09-08T23:11:44Z
dc.date.available2023-03-13T18:10:48Z
dc.date.issued2016
dc.format.mimetypepdf
dc.identifier.doiDOI: 10.1177/1534735416628273
dc.identifier.issn1552-695X
dc.identifier.urihttps://hdl.handle.net/1843/50855
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofIntegrative Cancer Therapies
dc.rightsAcesso Aberto
dc.subjectÁcido ursólico
dc.subjectRessonância magnética
dc.subjectCâncer de mama
dc.subjectCâncer - Cérebro
dc.subject.otherAntiangiogenic
dc.subject.otherUrsolic acid
dc.subject.otherDynamic contrast-enhanced magnetic resonance imaging
dc.subject.otherHuman breast tumor
dc.subject.otherMurine brain cancer
dc.subject.otherLong-circulating and pH-sensitive liposomes
dc.titleEvaluation of antitumor activity of long-circulating and ph-sensitive liposomes containing ursolic acid in animal models of breast tumor and gliosarcoma.
dc.typeArtigo de periódico
local.citation.epage524
local.citation.issue4
local.citation.spage512
local.citation.volume15
local.description.resumoUrsolic acid (UA) is a triterpene found in different plant species, possessing antitumor activity, which may be a result of its antiangiogenic effect. However, UA has low water solubility, which limits its use because the bioavailability is impaired. To overcome this inconvenience, we developed long-circulating and pH-sensitive liposomes containing ursolic acid (SpHL-UA). We investigated the antiangiogenic effect of free UA and SpHL-UA in murine brain cancer and human breast tumor models by means of determination of the relative tumor volume, dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), and histopathological analysis. Methods. The animals were treated with dimethyl sulfoxide in 0.9% (w/v) NaCl, free UA, long-circulating and pH-sensitive liposomes without drug (SpHL), or SpHL-UA. The animals were submitted to each treatment by intraperitoneal injection for 5 days. The dose of free UA or SpHL-UA was equal to 23 mg/kg. Results. Tumor growth inhibition was not observed in human breast tumor–bearing animals. For murine gliosarcoma-bearing animals, a slight tumor growth inhibition was observed in the groups treated with free UA or SpHL-UA (9% and 15%, respectively). No significant change in any of the parameters evaluated by DCE-MRI for both experimental models could be observed. Nevertheless, the evaluation of the mean values of magnetic resonance parameters of human breast tumor–bearing animals showed evidence of a possible antiangiogenic effect induced by SpHL-UA. Histopathological analysis did not present significant change for any treatment. Conclusion. SpHL-UA did not show antiangiogenic activity in a gliosarcoma model and seemed to induce an antiangiogenic effect in the human breast tumor model.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://journals.sagepub.com/doi/epub/10.1177/1534735416628273

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