Arthritis-induced alveolar bone loss is associated with changes in the composition of oral microbiota

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dc.creatorJôice Dias Corrêa
dc.creatorAdriana Machado Saraiva
dc.creatorCelso Martins Queiroz-Junior
dc.creatorMila Fernandes Moreira Madeira
dc.creatorPoliana Mendes Duarte
dc.creatorMauro Martins Teixeira
dc.creatorDanielle Glória Souza
dc.creatorTarcília Aparecida da Silva
dc.date.accessioned2025-04-16T16:33:09Z
dc.date.accessioned2025-09-08T23:43:13Z
dc.date.available2025-04-16T16:33:09Z
dc.date.issued2016-06
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.anaerobe.2016.03.006
dc.identifier.issn1095-8274
dc.identifier.urihttps://hdl.handle.net/1843/81666
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofAnaerobe
dc.rightsAcesso Restrito
dc.subjectArthritis
dc.subjectMicrobiota
dc.subjectPeriodontal diseases
dc.subjectAlveolar bone loss
dc.subjectBacteria
dc.subject.otherArthritis
dc.subject.otherMicrobiota
dc.subject.otherPeriodontal disease
dc.titleArthritis-induced alveolar bone loss is associated with changes in the composition of oral microbiota
dc.typeArtigo de periódico
local.citation.epage96
local.citation.spage91
local.citation.volume39
local.description.resumoRheumatoid arthritis (RA) and periodontitis (PD) are chronic inflammatory disorders that cause bone loss. PD tends to be more prevalent and severe in RA patients. Previous experimental studies demonstrated that RA triggers alveolar bone loss similarly to PD. The aim of this study was to investigate if arthritis-induced alveolar bone loss is associated with modification in the oral microbiota. Checkerboard DNA-DNA hybridization was employed to analyze forty oral bacterial species in 3 groups of C57BL/6 mice: control (n = 12; without any challenge); Y4 (n = 8; received oral inoculation of Aggregatibacter Actinomycetemcomitans strain FDC Y4) and AIA group (n = 12; chronic antigen-induced arthritis). The results showed that AIA and Y4 group exhibited similar patterns of bone loss. The AIA group exhibited higher counts of most bacterial species analyzed with predominance of Gram-negative species similarly to infection-induced PD. Prevotella nigrescens and Treponema denticola were detected only in the Y4 group whereas Campylobacter showae, Streptococcus mitis and Streptococcus oralis were only found in the AIA group. Counts of Parvimonas micra, Selenomonas Noxia and Veillonella parvula were greater in the AIA group whereas Actinomyces viscosus and Neisseira mucosa were in large proportion in Y4 group. In conclusion, AIA is associated with changes in the composition of the oral microbiota, which might account for the alveolar bone loss observed in AIA mice.
local.identifier.orcidhttps://orcid.org/0000-0003-0170-6163
local.identifier.orcidhttps://orcid.org/0000-0002-7884-7709
local.identifier.orcidhttps://orcid.org/0000-0002-1770-9978
local.identifier.orcidhttps://orcid.org/0000-0002-6944-3008
local.identifier.orcidhttps://orcid.org/0000-0001-9623-7835
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/abs/pii/S1075996416300208?via%3Dihub

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