Inflammaging in endemic areas for infectious diseases

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dc.creatorMarina Andrade Batista
dc.creatorTatiani Uceli Maioli
dc.creatorRodrigo Ribeiro Dos Santos
dc.creatorPatrizia Brigidi
dc.creatorClaudio Franceschi
dc.creatorAna Maria Caetano Faria
dc.creatorFernanda Calvo-fortes
dc.creatorGabriela Silveira-nunes
dc.creatorGiovanna Caliman Camatta
dc.creatorElaine Speziali
dc.creatorSilvia Turroni
dc.creatorAndrea Teixeira-carvalho
dc.creatorOlindo A. Martins-Filho
dc.creatorNicola Neretti
dc.date.accessioned2024-03-20T20:10:02Z
dc.date.accessioned2025-09-09T00:55:10Z
dc.date.available2024-03-20T20:10:02Z
dc.date.issued2020-11-11
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3389/fimmu.2020.579972
dc.identifier.issn1664-3224
dc.identifier.urihttps://hdl.handle.net/1843/66192
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofFrontiers in Immunology
dc.rightsAcesso Aberto
dc.subjectDieta
dc.subjectInflamação
dc.subjectMicrobiota
dc.subjectGenética
dc.subjectInfecção Persistente
dc.subjectEnvelhecimento
dc.subject.otherAging
dc.subject.otherInflammation
dc.subject.otherChronic infection
dc.subject.otherGenetics
dc.subject.otherMicrobiota
dc.subject.otherDietary components
dc.subject.otherInflammaging
dc.titleInflammaging in endemic areas for infectious diseases
dc.typeArtigo de periódico
local.citation.epage18
local.citation.spage579972
local.citation.volume11
local.description.resumoImmunosenescence is marked by a systemic process named inflammaging along with a series of defects in the immunological activity that results in poor responses to infectious agents and to vaccination. Inflammaging, a state of low-grade chronic inflammation, usually leads to chronic inflammatory diseases and frailty in the elderly. However, some elderly escape from frailty and reach advanced age free of the consequences of inflammaging. This process has been called immunological remodeling, and it is the hallmark of healthy aging as described in the studies of centenarians in Italy. The biological markers of healthy aging are still a matter of debate, and the studies on the topic have focused on inflammatory versus remodeling processes and molecules. The sub-clinical inflammatory status associated with aging might be a deleterious event for populations living in countries where chronic infectious diseases are not prevalent. Nevertheless, in other parts of the world where they are, two possibilities may occur. Inflammatory responses may have a protective effect against these infectious agents. At the same time, the long-term consequences of protective immune responses during chronic infections may result in accelerated immunosenescence in these individuals. Therefore, the biological markers of healthy aging can vary according to environmental, cultural, and geographical settings that reflect worldwide, and in a non-biased, non-westernized perspective, the changes that we experience regarding our contacts with microorganisms and the outcomes of such contacts
local.identifier.orcidhttps://orcid.org/0000-0002-7538-3208
local.publisher.countryBrasil
local.publisher.departmentENF - DEPARTAMENTO DE NUTRIÇÃO
local.publisher.departmentENFERMAGEM - ESCOLA DE ENFERMAGEM
local.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.579972/full

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