Avaliação do efeito anti-hipertensivo e ergogênico de um peptídeo da peçonha do escorpião tityus serrulatus em modelo murino

Abstract

The search for new therapeutic approaches against hypertension has encouraged the investigation of bioactive molecules, including peptides derived from animal toxins. In this context, this dissertation examines the effects of KPP, a synthetic tripeptide inspired by a toxin present in the venom of the scorpion Tityus serrulatus, on blood pressure and physical performance under different environmental conditions. To achieve this, experiments were conducted using normotensive and hypertensive murine models, as well as mice subjected to exercise protocols, allowing a comprehensive evaluation of KPP’s influence on cardiovascular response and physical capacity. The findings revealed that, in hypertensive rats (SHR), KPP significantly reduced mean arterial pressure (MAP) at both evaluated doses (33 and 330 μg/kg), while this effect was not significant in normotensive animals, demonstrating its antihypertensive but not hypotensive effect. KPP did not induce the same effect in females as observed in males; however, this discrepancy may be due to the smaller sample size used for female rats. In tests involving mice subjected to physical training, the peptide did not show a positive impact on muscle strength or aerobic endurance, reinforcing the absence of ergogenic properties associated with doping. Additionally, the results did not indicate significant inhibition of angiotensin-converting enzyme (ACE), suggesting that its hypotensive effect may occur through alternative pathways. These findings position KPP as a promising candidate for the development of new antihypertensive therapies, particularly for physically active hypertensive individuals. The lack of impact on athletic performance indicates that its use would not pose doping-related risks, making it a viable alternative for clinical applications. Future studies should further investigate its formulation and bioavailability to ensure its therapeutic efficacy and safety.