Alpha-tocopheryl succinate improves encapsulation, pH-sensitivity, antitumor activity and reduces toxicity of doxorubicin-loaded liposomes

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dc.creatorFernanda Alves Boratto
dc.creatorMarina Santiago Franco
dc.creatorAndré Luís Branco de Barros
dc.creatorGeovanni Dantas Cassali
dc.creatorÂngelo Malachias de Souza
dc.creatorLucas Antônio Miranda Ferreira
dc.creatorElaine Amaral Leite
dc.date.accessioned2023-03-16T17:53:37Z
dc.date.accessioned2025-09-08T23:39:09Z
dc.date.available2023-03-16T17:53:37Z
dc.date.issued2020
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.ejps.2019.105205
dc.identifier.issn0928-0987
dc.identifier.urihttps://hdl.handle.net/1843/50960
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofEuropean Journal of Pharmaceutical Sciences
dc.rightsAcesso Restrito
dc.subjectCâncer de mama
dc.subjectAgentes antineoplásicos
dc.subject.otherBreast cancer
dc.subject.otherDoxorubicin
dc.subject.otherAlpha-tocopheryl succinate
dc.subject.otherAntitumor activity
dc.subject.otherCytotoxicity
dc.subject.otherPH-sensitivity
dc.titleAlpha-tocopheryl succinate improves encapsulation, pH-sensitivity, antitumor activity and reduces toxicity of doxorubicin-loaded liposomes
dc.typeArtigo de periódico
local.citation.epage12
local.citation.spage1
local.citation.volume144
local.description.resumoDoxorubicin (DOX) plays an important role in cancer treatment; however, high cardiotoxicity and low penetration in solid tumors are the main limitations of its use. Liposomal formulations have been developed to attenuate the DOX toxicity, but the technological enhancement of the liposomal formulation as well as the addition of another agent with antitumor properties, like alpha-tocopheryl succinate (TS), a semi-synthetic analog of vitamin E, could certainly bring benefits. Thus, in this study, it was proposed the development of liposomes composed of DOX and TS (pHSL-TS-DOX). A new DOX encapsulation method, without using the classic ammonium sulfate gradient with high encapsulation percentage was developed. Analysis of Small Angle X-ray Scattering (SAXS) and release study proved the pH-sensitivity of the developed formulation. It was observed stabilization of tumor growth using pHSL-TS-DOX when compared to free DOX. The toxicity tests showed the safety of this formulation since it allowed body weight initial recovery after the treatment and harmless to heart and liver, main target organs of DOX toxicity. The developed formulation also avoided the occurrence of myelosuppression, a typical adverse effect of DOX. Therefore, pHSL-TS-DOX is a promising alternative for the treatment of breast cancer since it has adequate antitumor activity and a safe toxicity profile.
local.identifier.orcidhttps://orcid.org/0000-0003-4610-1328
local.identifier.orcidhttps://orcid.org/0000-0002-5650-6743
local.identifier.orcidhttps://orcid.org/0000-0002-8703-4283
local.identifier.orcidhttps://orcid.org/0000-0003-2474-5536
local.identifier.orcidhttps://orcid.org/0000-0001-8812-3811
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0928098719304786

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