Effect of conjugated linoleic acid-enriched butter after 24 hours of intestinal mucositis induction

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dc.creatorPatrícia Aparecida Vieira de Barros
dc.creatorSimone de Vasconcelos Generoso
dc.creatorMaria Emília Rabelo Andrade
dc.creatorMarco Antonio Sundfeld da Gama
dc.creatorFernando Cesar Ferraz Lopes
dc.creatorÉricka Lorenna de Sales Souza e Melo
dc.creatorFlaviano dos Santos Martins
dc.creatorSued Eustáquio Mendes Miranda
dc.creatorSimone Odília Antunes Fernandes
dc.creatorValbert Nascimento Cardoso
dc.date.accessioned2022-02-24T13:54:13Z
dc.date.accessioned2025-09-09T00:21:23Z
dc.date.available2022-02-24T13:54:13Z
dc.date.issued2016
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doi10.1080/01635581.2016.1225100
dc.identifier.issn01635581
dc.identifier.urihttps://hdl.handle.net/1843/39648
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofNutrition and Cancer
dc.rightsAcesso Restrito
dc.subjectDieta
dc.subjectManteiga
dc.subject.otherMucositis
dc.subject.otherButter
dc.titleEffect of conjugated linoleic acid-enriched butter after 24 hours of intestinal mucositis induction
dc.typeArtigo de periódico
local.citation.epage175
local.citation.issue1
local.citation.spage168
local.citation.volume69
local.description.resumoMucositis is the most common side effect due to chemotherapy or radiotherapy. It refers to the inflammation of intestinal mucous membranes, and it is associated with complications such as diarrhea, weight loss, and increased intestinal permeability (IP). This study was designed to evaluate the effect of diet containing conjugated linoleic acid (CLA)-enriched butter on intestinal damage and inflammatory response after 24 h of 5-fluorouracil (5-FU)-induced mucositis. Mice were divided into four groups: CTL; CLA; 5-FU, and CLA 5-FU, and they were fed for 31 days. On the 30th experimental day, mucositis was induced by unique injection of 300 mg/kg of 5-FU. After 24 h (31st experimental day), IP was evaluated; ileum and fecal material were collected to determine cytokine level and myeloperoxidase (MPO) activity and secretory immunoglobulin A (sIgA). The 5-FU group showed an increase in IP and MPO activity (CTL vs. 5-FU: P < 0.05). Additionally, increased levels of IP and MPO were observed in CLA 5-FU group compared to those in the test groups (P < 0.05). Animals in the CLA 5-FU group showed reduced concentrations of sIgA (CTL vs. CLA 5-FU: P < 0.05). CLA-enriched butter exacerbating the 5-FU-induced intestinal damage. Safety concerns regarding the use of CLA require further investigation.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.initialsUFMG
local.url.externahttps://www.tandfonline.com/doi/abs/10.1080/01635581.2016.1225100?journalCode=hnuc20

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