LNO3 and L3 are associated with antiproliferative and pro-apoptotic action in hepatoma cells

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dc.creatorLeonardo Campos Zanelatto
dc.creatorPatrícia Benites Gonçalves da Silva
dc.creatorDaniele Sartori
dc.creatorSandra Lepri
dc.creatorÂngelo de Fátima
dc.creatorMário Sérgio Mantovani
dc.date.accessioned2024-02-28T17:45:36Z
dc.date.accessioned2025-09-09T00:37:57Z
dc.date.available2024-02-28T17:45:36Z
dc.date.issued2016
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipOutra Agência
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1590/1678-4685-GMB-2015-0184
dc.identifier.issn1678-4685
dc.identifier.urihttps://hdl.handle.net/1843/64884
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofGenetics and Molecular Biology
dc.rightsAcesso Aberto
dc.subjectBioquímica
dc.subjectQuímica
dc.subjectÓxido nítrico
dc.subjectReações de radicais livres
dc.subjectApoptose
dc.subjectAgentes antineoplásicos
dc.subject.otherNitric oxide donating drug
dc.subject.otherNitric oxide
dc.subject.otherFree radical scavenging
dc.subject.otherApoptosis
dc.subject.otherAntiproliferative activity
dc.subject.otherThalidomide analogues
dc.titleLNO3 and L3 are associated with antiproliferative and pro-apoptotic action in hepatoma cells
dc.typeArtigo de periódico
local.citation.epage278
local.citation.issue2
local.citation.spage270
local.citation.volume39
local.description.resumoThe identification of antitumoral substances is the focus of intense biomedical research. Two structural analogues of thalidomide, LNO3 and L3, are two synthetic compounds that might possess such antitumor properties. We evaluated the toxicological effects of these substances, including cytotoxicity, genotoxicity and induction of apoptosis in HTC cells. Additionally, the production of free radicals (nitric oxide and superoxide) was investigated, and the expression of caspases genes 3, 8, and 9 were determined by RT-qPCR. The compounds exhibited cytotoxic effects that resulted in inhibited cell proliferation. LNO3 showed to be more effective and toxic than L3 in all assays. LNO3 stimulated the release of NO and superoxide, which was accompanied by the formation of peroxynitrite. Apoptosis was induced in a dose-dependent manner by both compounds; however, the expression of caspases 3, 8 and 9 was unchanged. These results suggested that L3 and LNO3 possess antiproliferative and pro-apoptotic effects in HTC cells. Additionally, although they exhibited cytotoxicity, L3 and LNO3 might be useful coadjuvants in tumor treatment studies.
local.identifier.orcidhttps://orcid.org/0000-0002-9091-0766
local.identifier.orcidhttps://orcid.org/0000-0002-0465-9932
local.identifier.orcidhttps://orcid.org/0000-0003-2344-5590
local.identifier.orcidhttps://orcid.org/0000-0003-3479-645X
local.identifier.orcidhttps://orcid.org/0000-0001-5268-6508
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/gmb/a/VSCtR4XRPdmK7Ydk8xfwS4Q/

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