Management of oral leukoplakia with an 808-nm high-power diode laser: a single-center experience

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dc.creatorJosé Alcides Almeida de Arruda
dc.creatorLeni Verônica de Oliveira Silva
dc.creatorCamila de Nazaré Alves de Oliveira Kato
dc.creatorJoão de Jesus Viana Pinheiro
dc.creatorLucas Guimarães Abreu
dc.creatorTarcília Aparecida da Silva
dc.creatorMarcus Vinícius Lucas Ferreira
dc.creatorLeandro Napier de Souza
dc.creatorRicardo Alves de Mesquita
dc.date.accessioned2025-05-14T18:54:24Z
dc.date.accessioned2025-09-09T00:33:59Z
dc.date.available2025-05-14T18:54:24Z
dc.date.issued2023
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1007/s10103-023-03806-1
dc.identifier.issn1435-604X
dc.identifier.urihttps://hdl.handle.net/1843/82271
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofLasers in Medical Science
dc.rightsAcesso Restrito
dc.subjectLasers, semiconductor
dc.subjectLaser therapy
dc.subjectLeukoplakia, oral
dc.subjectTreatment outcome
dc.subjectEvaluation study
dc.subjectTherapeutics
dc.subjectRecurrence
dc.subjectEfficacy
dc.subjectPain
dc.subject.otherDiode laser
dc.subject.otherLaser surgery
dc.subject.otherOral leukoplakia
dc.subject.otherOral potentially malignant disorders
dc.subject.otherTreatment outcome
dc.titleManagement of oral leukoplakia with an 808-nm high-power diode laser: a single-center experience
dc.typeArtigo de periódico
local.citation.epage8
local.citation.issue141
local.citation.spage1
local.citation.volume38
local.description.resumoPurpose: High-power diode laser emerges as a promising approach to the treatment of oral leukoplakia (OL); however, its short- and long-term effects have been barely explored. This study evaluated the postoperative endpoints and the recurrence rate of high-power diode laser treatment in a well-defined series of patients with OL. Methods: A prospective analysis was performed on 22 individuals comprising 31 OL. The lesions were irradiated using the following protocol: Indium-Gallium-Arsenide diode laser, 808 nm, continuous-wave mode, 1.5-2.0 W, 780.0 ± 225.1 J, and 477.1 ± 131.8 s. Postoperative pain was assessed with a visual analog scale at three endpoints. Clinical follow-up was performed on all patients and the Kaplan-Meier test was used to analyze the probability of recurrence. Results: The series consisted mostly of women (72.7%) with a mean age of 62.8 years. A single laser session was performed in 77.4% of cases. The median score on the scale that assessed pain on the 1st, 14th and 42nd postoperative day was 4, 1, and 0, respectively. The mean follow-up period per lesion was 28.6 months (range: 2-53 months). A complete response was observed in 93.5% of OL cases, while 6.5% had recurrence. The probability of recurrence at 39 months was 6.7%. No patient experienced malignant transformation. Conclusion: High-power diode laser for the treatment of OL is safe and effective during the trans- and postoperative period. These findings represent an alternative approach to the management of OL, mainly because a low recurrence rate was observed.
local.identifier.orcidhttps://orcid.org/0000-0002-6599-3950
local.identifier.orcidhttps://orcid.org/0000-0003-0336-9359
local.identifier.orcidhttps://orcid.org/0000-0001-9963-1707
local.identifier.orcidhttps://orcid.org/0000-0002-6914-6441
local.identifier.orcidhttps://orcid.org/0000-0003-2258-8071
local.identifier.orcidhttps://orcid.org/0000-0001-9623-7835
local.identifier.orcidhttps://orcid.org/0000-0003-1137-9776
local.identifier.orcidhttps://orcid.org/0000-0002-9479-4993
local.identifier.orcidhttps://orcid.org/0000-0003-3207-4007
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIA
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s10103-023-03806-1

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