The new psychoactive substances 25H-NBOMe and 25H-NBOH induce abnormal development in the zebrafish embryo and interact in the DNA major groove

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dc.creatorWellington Alves de Barros
dc.creatorÂngelo de Fátima
dc.creatorCamila da Silva Nunes
dc.creatorJuliana Alves da Costa Ribeiro Souza
dc.creatorIgor José dos Santos Nascimento
dc.creatorIsis Martins Figueiredo
dc.creatorThiago Mendonça de Aquino
dc.creatorLeonardo Vieira
dc.creatorDavi Felipe Farias
dc.creatorJosué Carinhanha Caldas Santos
dc.date.accessioned2024-11-12T18:49:52Z
dc.date.accessioned2025-09-08T23:05:49Z
dc.date.available2024-11-12T18:49:52Z
dc.date.issued2021
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.crtox.2021.11.002
dc.identifier.issn2666-027X
dc.identifier.urihttps://hdl.handle.net/1843/77990
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofCurrent Research in Toxicology
dc.rightsAcesso Aberto
dc.subjectDrogas - Toxicologia
dc.subjectFenetilamina
dc.subjectDrogas - Uso recreativo
dc.subjectDNA
dc.subjectAlucinógenos
dc.subjectEspectroscopia de fluorescência
dc.subjectEspectroscopia de ressonância nuclear
dc.subject.otherPhenethylamines
dc.subject.otherIlicit Drugs
dc.subject.otherDNA interaction
dc.subject.otherZebra fish
dc.subject.otherNBOHs
dc.subject.otherNBOMes
dc.titleThe new psychoactive substances 25H-NBOMe and 25H-NBOH induce abnormal development in the zebrafish embryo and interact in the DNA major groove
dc.typeArtigo de periódico
local.citation.epage398
local.citation.spage386
local.citation.volume2
local.description.resumoToxicological effects of 25H-NBOMe and 25H-NBOH recreational drugs on zebrafish embryos and larvae at the end of 96 h exposure period were demonstrated. 25H-NBOH and 25H-NBOMe caused high embryo mortality at 80 and 100 µg mL−1, respectively. According to the decrease in the concentration tested, lethality decreased while non-lethal effects were predominant up to 10 and 50 µg mL−1 of 25H-NBOH and 25H-NBOMe, respectively, including spine malformation, egg hatching delay, body malformation, otolith malformation, pericardial edema, and blood clotting. We can disclose that these drugs have an affinity for DNA in vitro using biophysical spectroscopic assays and molecular modeling methods. The experiments demonstrated that 25H-NBOH and 25H-NBOMe bind to the unclassical major groove of ctDNA with a binding constant of 27.00 × 104 M−1 and 5.27 × 104 M−1, respectively. Furthermore, these interactions lead to conformational changes in the DNA structure. Therefore, the results observed in the zebrafish embryos and DNA may be correlated.
local.identifier.orcidhttps://orcid.org/0000-0002-3479-0720
local.identifier.orcidhttps://orcid.org/0000-0003-2344-5590
local.identifier.orcidhttps://orcid.org/0000-0002-2664-4336
local.identifier.orcidhttps://orcid.org/0000-0002-1873-5342
local.identifier.orcidhttps://orcid.org/0000-0001-9138-8466
local.identifier.orcidhttps://orcid.org/0000-0002-9525-5123
local.identifier.orcidhttps://orcid.org/0000-0001-5438-1919
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S2666027X21000402?via%3Dihub

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