Efeito do propionato de sódio na resposta tipo corpo estranho induzida por implante sintético em modelo murino

Abstract

Beyond its actions on the intestine, the short-chain acid (SCFA), propionate has been shown to lower inflammation and modulate angiogenesis and fibrogenesis in pathological conditions in esperimental animal models. However, its effects on foreign body reaction (FBR), a complex adverse healing process, after implantation of biomedical/synthetic devices have not been reported. We have evaluated the effects of sodium propionate (SP) on inflammation, neovascularization and remodeling on a murine model of implant induced FBR. Polyether-polyurethane sponge discs were implanted subcutaneously in C57/BI6 mice to induce this response. The animal were treated daily with oral administration of SP (100 mg/kg) for 14 consecutive days. The treatment started on the day after surgery and the implants were removed after 14 days. SP was able to decrease the inflammatory parameters (cytometry and inflammatory enzime activities, myeloperoxidase and N-acetyl-β-D-glucosaminidase). Angiogenesis, as evaluated by blood vessel number and VEGF levels downregulated by the treatment. Most importantly, the number of foreign body giant cells (FBGC) and the thickness of the collagenous capsule were reduced by 58% and 34%, respectively, as the collagenous deposition inside the implant. The effects of SP described here expands its range of actions as a potential agente able to attenuate fibroproliferative processes that can impair functionality of implantable devices.