Curcumin improves metabolic response and increases expression of thermogenesis-associated markers in adipose tissue of male offspring from obese dams

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dc.creatorAugusto Cândido Correia Santos
dc.creatorLílian Betânia Reis Amaro
dc.creatorAntônio Henrique Batista Jorge
dc.creatorSarah de Farias Lelis
dc.creatorDeborah de Farias Lelis
dc.creatorAndré Luiz Sena Guimarães
dc.creatorSérgio Henrique Sousa Santos
dc.creatorJoão Marcus Oliveira Andrade
dc.date.accessioned2024-10-10T19:07:34Z
dc.date.accessioned2025-09-09T00:52:13Z
dc.date.available2024-10-10T19:07:34Z
dc.date.issued2023-03
dc.identifier.doihttps://doi.org/10.1016/j.mce.2022.111840
dc.identifier.issn1872-8057
dc.identifier.urihttps://hdl.handle.net/1843/77363
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofMolecular and Cellular Endocrinology
dc.rightsAcesso Restrito
dc.subjectCúrcuma
dc.subjectPlantas - Compostos bioativos
dc.subjectObesidade em mulheres
dc.subjectTecido adiposo
dc.subjectPolifenóis
dc.titleCurcumin improves metabolic response and increases expression of thermogenesis-associated markers in adipose tissue of male offspring from obese dams
dc.typeArtigo de periódico
local.citation.spage111840
local.citation.volume563
local.description.resumoMaternal obesity and dietary style in the pregnancy-lactation period may result in long-term effects on the metabolic health of the offspring, thus increasing the risk of diseases, such as obesity, diabetes, and cardiovascular diseases. Curcumin is a natural polyphenolic compound that has beneficial properties on metabolism. Accordingly, this study is intended to evaluate the effects of curcumin supplementation in pregnant and lactating female mice on the anthropometric, metabolic and molecular parameters of the offspring fed a hyperglycemic diet. The study was conducted with 24 male mice randomized into three groups: i) control group (SD) originating from dams fed a standard diet; ii) hyperglycemic group (HGD) originating from dams fed a hyperglycemic diet; iii) curcumin group (CUR) originating from dams fed a hyperglycemic diet and supplemented with curcumin in the pregnancy-lactation period. All offspring groups were fed a hyperglycemic diet for 12 weeks. Anthropometricand biochemical parameters were measured, as well as the expression of thermogenesis-associated markers in the interscapular brown and inguinal white adipose tissues. The results showed less weight gain in the CUR group, with a concomitant reduction in food consumption compared to the HGD group. Biochemical parameters indicated lower levels of total cholesterol, glucose, and insulin for the CUR group, in addition to improved glucose tolerance and insulin sensitivity. The molecular evaluation indicated increased mRNA expression levels of UCP1 and PRDM16 in the brown and white adipose tissues. It is concluded that curcumin supplementation in the pregnancy-lactation period in dams with diet-induced obesity may lead to improvements in the offspring's metabolic phenotype, even if they are submitted to an obesogenic environment, possibly via thermogenesis activation.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S030372072200288X

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