Unveiling metabolic changes in marsupialized odontogenic keratocyst: a pilot study

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dc.creatorFlávia Leite Lima
dc.creatorVictor Rezende Moreira
dc.creatorLucilaine Valéria de Souza Santos
dc.creatorLiséte Celina Lange
dc.creatorAdriana Nori de Macedo
dc.creatorMarina Gonçalves Diniz
dc.creatorCarolina Cavaliéri Gomes
dc.creatorWagner Henriques de Castro
dc.creatorGisele André Baptista Canuto
dc.creatorRicardo Santiago Gomez
dc.creatorVictor Coutinho Bastos
dc.creatorJéssica Gardone Vitório
dc.creatorFilipe Fideles Duarte-Andrade
dc.creatorThaís dos Santos Fontes Pereira
dc.creatorRoberta Rayra Martins Chaves
dc.creatorAline Fernanda Cruz
dc.creatorJúlio César Tanos de Lacerda
dc.creatorYuri Abner Rocha Lebron
dc.date.accessioned2023-11-07T19:05:24Z
dc.date.accessioned2025-09-09T00:15:24Z
dc.date.available2023-11-07T19:05:24Z
dc.date.issued2022
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipOutra Agência
dc.identifier.doihttps://doi.org/10.1111/odi.13913
dc.identifier.issn1354-523X
dc.identifier.urihttps://hdl.handle.net/1843/60574
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOral Diseases
dc.rightsAcesso Restrito
dc.subjectTumores odontogênicos
dc.subjectBoca - Tumores
dc.subjectMucosa bucal
dc.subjectCromatografia líquida de alta eficiência
dc.subjectEspectrometria de massa
dc.subject.otherMarsupialization
dc.subject.otherOral mucosa
dc.subject.otherOdontogenic keratocyst (OKC)
dc.subject.otherHigh-performance liquid chromatography
dc.subject.otherMass spectrometry
dc.subject.otherNevoid basal cell carcinoma syndrome (NBCCS)
dc.titleUnveiling metabolic changes in marsupialized odontogenic keratocyst: a pilot study
dc.typeArtigo de periódico
local.citation.epage2229
local.citation.issue8
local.citation.spage2219
local.citation.volume28
local.description.resumoObjective: We aimed to assess which metabolic pathways would be implicated in the phenotypic changes of the epithelial lining of odontogenic keratocyst after marsupialization, comparing pre- and post-marsupialized lesions with adjacent oral mucosa. Materials and Methods: Eighteen formalin-fixed and paraffin-embedded tissues from six subjects were divided into three paired groups: odontogenic keratocyst pre- (n = 6) and post-marsupialization (n = 6), and adjacent oral mucosa (n = 6). The metabolic pathways found in these groups were obtained by high-performance liquid chromatography-mass spectrometry-based untargeted metabolomics performed. Results: Through putative metabolite annotation followed by pathway enrichment and predictive analysis with automated algorithms (Mummichog and Gene Set Enrichment Analysis), we found differences in many cellular processes that may be involved in inflammation, oxidative stress response, keratinocyte-basal membrane attachment, differentiation, and proliferation functions, all relevant to odontogenic keratocyst pathobiology and the phenotype acquired after marsupialization.Conclusion: Our study was able to identify several metabolic pathways potentially involved in the metaplastic changes induced by marsupialization of odontogenic keratocysts. An improved comprehension of this process could pave the way for the development of targeted therapies.
local.identifier.orcidhttps://orcid.org/0000-0001-6368-3310
local.identifier.orcidhttps://orcid.org/0000-0002-2615-2948
local.identifier.orcidhttps://orcid.org/0000-0001-9002-3297
local.identifier.orcidhttps://orcid.org/0000-0002-5768-8729
local.identifier.orcidhttps://orcid.org/0000-0003-1580-4995
local.identifier.orcidhttps://orcid.org/0000-0003-0345-0376
local.identifier.orcidhttps://orcid.org/0000-0001-6182-9232
local.identifier.orcidhttps://orcid.org/0000-0002-5570-3550
local.identifier.orcidhttps://orcid.org/0000-0001-6933-8454
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/full/10.1111/odi.13913

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