Papel do sistema renina angiotensina na síndrome metabólica: influência das adipocinas

Abstract

The Renin Angiotensin System (RAS)isan important physiological system, playing a main role on blood pressure regulation. In addition to systemic effects, RAS is also found locally in several organs and tissues, such as the liver, adipose tissue, kidney, and pancreas, where different RAS peptides, namelyangiotensin I, II, III, IV, and 1- 7, act in specific receptors to controlhomeostasis. RAS over activation, particularly through its classical pathway,reveals an important connection with factors involved in metabolic syndrome, such as obesity development and insulin resistance. Obesity is related to adipose tissue inflammation andreduced functionality of adipocytes. Thus, inflammation is a major regulator factor to the synthesis of adipose tissue cytokines, the adipokines.The producedadipokines can lead to adipose tissue inflammation (TNF-), improveinsulin signaling (adiponectin), andmodulate blood pressure (leptin). Pharmacological treatments blocking RAS have shown significant improvementfor metabolic disorders seen in metabolic syndrome,highlighting the link between renin angiotensin system, metabolic syndrome, and adipokines.