Fibrates for the Treatment of Primary Biliary Cholangitis Unresponsive to Ursodeoxycholic Acid: An Exploratory Study

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dc.creatorGuilherme Grossi Lopes Cançado
dc.creatorLuciana Costa Faria
dc.creatorElze Maria Gomes de Oliveira
dc.creatorVivian Rotman
dc.creatorDaniel Ferraz de Campos Mazo
dc.creatorValéria Ferreira de Almeida e Borges
dc.creatorLiliana Sampaio Costa Mendes
dc.creatorLiana Codes
dc.creatorMario Guimarães Pessoa
dc.creatorIzabelle Venturini Signorelli
dc.creatorCynthia Levy
dc.creatorCláudia Alves Couto
dc.creatorPaulo Lisboa Bittencourt
dc.creatorLaura Vilar Guedes
dc.creatorMichelle Harriz Braga
dc.creatorDébora Raquel Benedita Terrabuio
dc.creatorEduardo Luiz Rachid Cançado
dc.creatorMaria Lucia Gomes Ferraz
dc.creatorCristiane Alves Villela-Nogueira
dc.creatorMateus Jorge Nardelli
dc.date.accessioned2023-11-06T20:34:27Z
dc.date.accessioned2025-09-08T23:07:33Z
dc.date.available2023-11-06T20:34:27Z
dc.date.issued2022-01-20
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3389/fphar.2021.818089
dc.identifier.issn1663-9812
dc.identifier.urihttps://hdl.handle.net/1843/60513
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofFrontiers in Pharmacology
dc.rightsAcesso Aberto
dc.subjectFalha de Tratamento
dc.subjectÁcidos Fíbricos
dc.subjectÁcido Ursodesoxicólico
dc.subjectCirrose Hepática Biliar
dc.subjectBezafibrato
dc.subject.otherBezafibrate
dc.subject.otherCiprofibrate
dc.subject.otherFibrate
dc.subject.otherPrimary biliary cholangitis
dc.subject.otherTreatment failure
dc.subject.otherUrsodeoxycholic acid
dc.titleFibrates for the Treatment of Primary Biliary Cholangitis Unresponsive to Ursodeoxycholic Acid: An Exploratory Study
dc.typeArtigo de periódico
local.citation.epage6
local.citation.spage818089
local.citation.volume12
local.description.resumoAim: Up to 40% of patients with primary biliary cholangitis (PBC) will have a suboptimal biochemical response to ursodeoxycholic acid (UDCA), which can be improved by the addition of fibrates. This exploratory study aims to evaluate the long-term real-life biochemical response of different fibrates, including ciprofibrate, in subjects with UDCA-unresponsive PBC. Methods: The Brazilian Cholestasis Study Group multicenter database was reviewed to assess the response rates to UDCA plus fibrates in patients with UDCA-unresponsive PBC 1 and 2 years after treatment initiation by different validated criteria. Results: In total, 27 patients (100% women, mean age 48.9 ± 9.2 years) with PBC were included. Overall response rates to fibrates by each validated criterion varied from 39 to 60% and 39–76% at 12 and 24 months after treatment combination, respectively. Combination therapy resulted in a significant decrease in ALT and ALP only after 2 years, while GGT significantly improved in the first year of treatment. Treatment response rates at 1 and 2 years appear to be comparable between ciprofibrate and bezafibrate using all available criteria. Conclusion: Our findings endorse the efficacy of fibrate add-on treatment in PBC patients with suboptimal response to UDCA. Ciprofibrate appears to be at least as effective as bezafibrate and should be assessed in large clinical trials as a possibly new, cheaper, and promising option for treatment of UDCA-unresponsive PBC patients.
local.identifier.orcidhttps://orcid.org/0000-0003-3664-4839
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentMEDICINA - FACULDADE DE MEDICINA
local.publisher.initialsUFMG
local.url.externahttps://www.frontiersin.org/articles/10.3389/fphar.2021.818089/full

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