Reduced Activated T Lymphocytes (CD4+CD25+) and Plasma Levels of Cytokines in Parkinson’s Disease

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dc.creatorNatalia Pessoa Rocha
dc.creatorFrankcinéia Assis
dc.creatorPaula Luciana Scalzo
dc.creatorÉrica Leandro Marciano Vieira
dc.creatorIzabela Guimarães Barbosa
dc.creatorMariana Soares de Souza
dc.creatorPaulo Pereira Christo
dc.creatorHelton José Reis
dc.creatorAntonio Lucio Teixeira Junior
dc.date.accessioned2023-07-17T20:12:27Z
dc.date.accessioned2025-09-08T22:54:49Z
dc.date.available2023-07-17T20:12:27Z
dc.date.issued2017-02-07
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1007/s12035-017-0404-y
dc.identifier.issn08937648
dc.identifier.urihttps://hdl.handle.net/1843/56492
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofMolecular Neurobiology
dc.rightsAcesso Restrito
dc.subjectDoença de Parkinson
dc.subjectSistema Imunitário
dc.subjectImunofenotipagem
dc.subjectLeucócitos
dc.subjectCitocinas
dc.subject.otherParkinson’s disease
dc.subject.otherImmune system
dc.subject.otherInflammation
dc.subject.otherImmunophenotyping
dc.subject.otherLeukocytes
dc.subject.otherCytokines
dc.titleReduced Activated T Lymphocytes (CD4+CD25+) and Plasma Levels of Cytokines in Parkinson’s Disease
dc.typeArtigo de periódico
local.citation.epage1497
local.citation.issue2
local.citation.spage1488
local.citation.volume55
local.description.resumoAbstract Parkinson’s disease (PD) is the second most com mon neurodegenerative disease. The cause of neurodegeneration in PD is not completely understood, and evidence has shown that inflammatory/immune changes may be involved in PD pathophysiology. Herein, we aimed to determine the profile of the peripheral immune system in patients with PD in comparison with controls. Forty patients with PD and 25 age- and gender-matched controls were enrolled in this study. From these, 23 PD patients and 21 controls were included in the immunophenotyping analyses. Peripheral blood was drawn on the same day of the clinical assessment and submitted to plasma separation for enzyme-linked immunosorbent assay or cytometric bead array. Immunophenotyping analyses of the peripheral blood were performed by flow cytometry. We found that patients with PD presented peripheral immune changes evidenced by decreased percentage of T lymphocytes (CD3+ cells), especially activated T lymphocytes (CD4+CD25+ cells), when compared with controls. In line with these results, we also found decreased plasma levels of the cytokines IL-4, IL-6, IL-10, TNF, IFN-γ, and IL-17A in the PD group. In vitro experiments demonstrated that the produc tion of cytokines by peripheral blood mononuclear cells harvested from healthy young donors was reduced after exposure to the anti-parkinsonian drugs levodopa and pramipexole. Our data corroborate the hypothesis that immunological mechanisms are involved in PD. It is not clear whether the differences that we have found are due to adaptive mechanisms or to changes associated with PD, including pharmacological treatment, or even directly related to the disease pathophysi ology. Future studies are needed in this regard.
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s12035-017-0404-y

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