Avaliação de fatores de risco para dislipidemia em pacientes diabéticos tipo 1

Abstract

Patients with DM1 may present clinical conditions triggeringalterations in their lipid profile, and considering the importance of controlling cardiovascular risk factors in these patients, the objective was to evaluate the presence of risk factors for dyslipidemia in type 1 diabetic patients, as well as their association with their lipid profile. The 125 patients included in this study were classified according to the presence or absence of various risk factors for dyslipidemia. Total cholesterol and triglycerides were determined by enzymatic colorimetric method, HDL cholesterol by precipitation method; HbA1c by immunoturbidimetry, as well as urinary albumin, which was then corrected by urinary creatinine, measured enzymatically. Normal distribution variables were compared by ANOVA and Student t-test and those without normal distribution were compared by the Kruskall Wallis test and the Mann-Whitney U test. Analyzing the investigated risk factors, it was found that hypertension, albuminuria, sedentary lifestyle, smoking, the use of statins, age and duration of diabetes are associated with increased triglyceride levels. Inadequate glucose control is associated with increased LDL cholesterol and total cholesterol; and hypothyroidism is not associated with significant changes in lipid profile, while BMI is associated with increased total cholesterol, LDL cholesterol and triglycerides, and reduced HDL cholesterol. Due to the increased cardiovascular risk in this population, the control of these risk factors assumes significant importance in preventing the development of more atherogenic profiles, as well the associated complications.