IFITM3, FURIN, ACE1, and TNF-α Genetic Association With COVID-19 Outcomes: Systematic Review and Meta-Analysis

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dc.creatorJoão Locke Ferreira de Araújo
dc.creatorDiego Menezes
dc.creatorRenato Santana de Aguiar
dc.creatorRenan Pedra de Souza
dc.date.accessioned2023-10-31T21:35:27Z
dc.date.accessioned2025-09-09T00:17:59Z
dc.date.available2023-10-31T21:35:27Z
dc.date.issued2022-04-01
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3389/fgene.2022.775246
dc.identifier.issn1664-8021
dc.identifier.urihttps://hdl.handle.net/1843/60396
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofFrontiers in Genetics
dc.rightsAcesso Aberto
dc.subjectGenomas
dc.subjectGenética
dc.subjectBiomarcadores
dc.subject.otherPolymorphism
dc.subject.otherGenetic association study
dc.subject.otherCandidate genes
dc.subject.otherTransposable elements
dc.subject.otherBiomarkers
dc.subject.otherHost genetics
dc.titleIFITM3, FURIN, ACE1, and TNF-α Genetic Association With COVID-19 Outcomes: Systematic Review and Meta-Analysis
dc.typeArtigo de periódico
local.citation.epage12
local.citation.spage775246
local.citation.volume13
local.description.resumoHuman polymorphisms may contribute to SARS-CoV-2 infection susceptibility and COVID-19 outcomes (asymptomatic presentation, severe COVID-19, death). We aimed to evaluate the association of IFITM3, FURIN, ACE1, and TNF-α genetic variants with both phenotypes using meta-analysis. The bibliographic search was conducted on the PubMed and Scielo databases covering reports published until February 8, 2022. Two independent researchers examined the study quality using the Q-Genie tool. Using the Mantel–Haenszel weighted means method, odds ratios were combined under both fixed- and random-effect models. Twenty-seven studies were included in the systematic review (five with IFITM3, two with Furin, three with TNF-α, and 17 with ACE1) and 22 in the meta-analysis (IFITM3 n = 3, TNF-α, and ACE1 n = 16). Meta-analysis indicated no association of 1) ACE1 rs4646994 and susceptibility, 2) ACE1 rs4646994 and asymptomatic COVID-19, 3) IFITM3 rs12252 and ICU hospitalization, and 4) TNF-α rs1800629 and death. On the other hand, significant results were found for ACE1 rs4646994 association with COVID-19 severity (11 studies, 692 severe cases, and 1,433 nonsevere controls). The ACE1 rs4646994 deletion allele showed increased odds for severe manifestation (OR: 1.45; 95% CI: 1.26–1.66). The homozygous deletion was a risk factor (OR: 1.49, 95% CI: 1.22–1.83), while homozygous insertion presented a protective effect (OR: 0.57, 95% CI: 0.45–0.74). Further reports are needed to verify this effect on populations with different ethnic backgrounds.
local.publisher.countryBrasil
local.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS
local.publisher.departmentMEDICINA - FACULDADE DE MEDICINA
local.publisher.initialsUFMG
local.url.externahttps://www.frontiersin.org/articles/10.3389/fgene.2022.775246/full

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