Molecular mechanisms associated with the benefits of variable practice in motor learning

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dc.creatorTércio Apolinário de Souza
dc.creatorAna Flávia Santos Almeida
dc.creatorNatália Lelis Torres
dc.creatorJuliana Otoni Parma
dc.creatorGrace Schenatto Pereira Moraes
dc.creatorGuilherme Menezes Lage
dc.date.accessioned2022-08-03T12:59:56Z
dc.date.accessioned2025-09-08T23:42:53Z
dc.date.available2022-08-03T12:59:56Z
dc.date.issued2020
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1080/00222895.2019.1649997
dc.identifier.issn1940-1027
dc.identifier.urihttps://hdl.handle.net/1843/43908
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Motor Behavior
dc.rightsAcesso Restrito
dc.subjectAprendizagem motora
dc.subjectExercícios físicos
dc.subjectCórtex motor
dc.subjectReceptores glutamatérgicos
dc.subject.otherMotor learning
dc.subject.otherPractice schedule
dc.subject.otherAMPA receptor
dc.subject.otherNMDA receptor
dc.titleMolecular mechanisms associated with the benefits of variable practice in motor learning
dc.typeArtigo de periódico
local.citation.epage526
local.citation.issue5
local.citation.spage515
local.citation.volume52
local.description.resumoVariable practice promotes a higher level of motor learning than constant practice. The glutamate receptors, n-methyl-d-aspartate (NMDA) and alfa-amino-3-hydroxy-5-methyl-4-isoxazolepropionic (AMPA), have been associated with the changes in motor cortex that occur throughout the process of motor learning. Considering that, it is possible that variable practice is more associated with the NMDA and AMPA receptors than constant practice. This study aimed ao investigating the association between the glutamate receptors, NMDA and AMPA, and constant and variable practice schedules. Seventy-eight male mice practiced the rotarod task in a constant or variable scheduling, in two consecutive days (acquisition phase). Learning tests were performed 24 h and 10 days after the end of the acquisition phase. Variable practice was more associated with the NMDA receptor and had a greater AMPA receptor expression than constant practice. The results suggest that the benefits of variable practice are result of both the greater dependency on the NMDA receptor and the greater AMPA receptor expression.
local.identifier.orcidhttp://orcid.org/0000-0002-2136-0238
local.identifier.orcidhttp://orcid.org/0000-0002-2860-0353
local.identifier.orcidhttp://orcid.org/0000-0002-3118-9921
local.identifier.orcidhttp://orcid.org/0000-0003-4371-7020
local.identifier.orcidhttp://orcid.org/0000-0001-8296-3676
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE EDUCAÇÃO FÍSICA
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.initialsUFMG
local.url.externahttps://www.tandfonline.com/doi/abs/10.1080/00222895.2019.1649997?journalCode=vjmb20#:~:text=Variable%20practice%20was%20more%20associated,the%20greater%20AMPA%20receptor%20expression.

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