Circulating leptin levels as a potential biomarker in inflammatory bowel diseases: a systematic review and meta-analysis

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dc.creatorLarissa Gabriela Ferreira de Carvalho
dc.creatorWilliam Gustavo Lima
dc.creatorLuiz Gonzaga Vaz Coelho
dc.creatorValbert Nascimento Cardoso
dc.creatorSimone Odília Antunes Fernandes
dc.date.accessioned2022-03-31T20:29:29Z
dc.date.accessioned2025-09-08T23:39:35Z
dc.date.available2022-03-31T20:29:29Z
dc.date.issued2021-02-25
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doi10.1093/ibd/izaa037
dc.identifier.issn1078-0998
dc.identifier.urihttps://hdl.handle.net/1843/40672
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofInflammatory Bowel Diseases
dc.rightsAcesso Aberto
dc.subjectDoenças inflamatórias intestinais
dc.subjectRevisão sistemática
dc.subject.otherAdipokines
dc.subject.otherCrohn’s disease
dc.subject.otherUlcerative colitis
dc.subject.otherPrognosis
dc.subject.otherDifferential diagnosis
dc.titleCirculating leptin levels as a potential biomarker in inflammatory bowel diseases: a systematic review and meta-analysis
dc.typeArtigo de periódico
local.citation.epage181
local.citation.issue2
local.citation.spage169
local.citation.volume27
local.description.resumoBackground The differential diagnosis of inflammatory bowel diseases (IBDs) between Crohn’s disease (CD) and ulcerative colitis (UC) is important for designing an effective therapeutic regimen. However, without any adequate gold standard method for differential diagnosis currently, therapeutic design remains a major challenge in clinical practice. In this context, recent studies have showed that circulating leptin stands out as a potential biomarker for the categorization of IBDs. Thus, we aimed to summarize the current understanding of the prognostic and diagnostic value of serum leptin in patients with IBDs. Methods A systematic search was performed in PubMed/MEDLINE, Scopus, Cochrane Library, and Web of Science databases. Articles that aimed to study the relationship between circulating levels of leptin and IBDs were included. Finally, the meta-analysis was performed with the mean serum leptin levels in patients with IBDs and healthy controls using RevMan 5.3 software, with I2 > 50% as a criterion for substantial heterogeneity. Results Nineteen studies were included. Serum leptin levels among patients with IBDs and healthy controls did not show a significant difference (95% CI, −2.15 to 0.57; I2, 86%, P ≤ 0.00001). Similarly, there was no association of leptin levels with the activity of IBDs (95% CI, −0.24 to 0.06; I2, 50%; P = 0.13). However, serum leptin levels were significantly higher in patients with CD than those in patients with UC (95% CI, −2.09 to −0.37; I2, 7%; P ≤ 0.36). Conclusion This review suggested that serum leptin levels might be a promising biomarker to help in the differentiation between CD and UC.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://academic.oup.com/ibdjournal/article/27/2/169/5756067

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