Relationship between adiponectin and leptin on osteocalcin in obese adolescents during weight loss therapy

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dc.creatorRaquel Munhoz da Silveira Campos
dc.creatorDeborah Cristina Landi Masquio
dc.creatorFlávia Campos Corgosinho
dc.creatorJoana Pereira de Carvalho Ferreira
dc.creatorBárbara Dal Molin Netto
dc.creatorAna Paula Grotti Clemente
dc.creatorLian Tock
dc.creatorSergio Tufik
dc.creatorMarco Túlio de Mello
dc.creatorAna Raimunda Dâmaso
dc.date.accessioned2023-03-03T17:10:20Z
dc.date.accessioned2025-09-08T23:13:36Z
dc.date.available2023-03-03T17:10:20Z
dc.date.issued2018-06
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.20945/2359-3997000000039
dc.identifier.issn2359-4292
dc.identifier.urihttps://hdl.handle.net/1843/50637
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.rightsAcesso Aberto
dc.subjectInflamação
dc.subjectRegeneração óssea
dc.subjectObesidade
dc.subjectAdolescentes
dc.subjectPerda de peso
dc.subject.otherInflammation
dc.subject.otherBone turnover markers
dc.subject.otherObesity
dc.subject.otherAdolescents
dc.subject.otherWeight loss
dc.titleRelationship between adiponectin and leptin on osteocalcin in obese adolescents during weight loss therapy
dc.typeArtigo de periódico
local.citation.epage284
local.citation.issue3
local.citation.spage275
local.citation.volume62
local.description.resumoObjectives: Obesity is a multifactorial disease characterized by the presence of the pro-inflammatory state associated with the development of many comorbidities, including bone turnover marker alterations. This study aimed to investigate the role of the inflammatory state on bone turnover markers in obese adolescents undergoing interdisciplinary weight loss treatment for one year. Subjects and methods: Thirty four post-pubescent obese adolescents with primary obesity, a body mass index (BMI) greater than > 95th percentile of the CDC reference growth charts, participated in the present investigation. Measurements of body composition, bone turnover markers, inflammatory biomarkers and visceral and subcutaneous fat were taken. Adolescents were submitted to one year of interdisciplinary treatment (clinical approach, physical exercise, physiotherapy intervention, nutritional and psychological counseling). Results: Reduction in body mass, body fat mass, visceral and subcutaneous fat, as well as, an increase in the body lean mass and bone mineral content was observed. An improvement in inflammatory markers was seen with an increase in adiponectin, adiponectin/leptin ratio and inteleukin-15. Moreover, a positive correlation between the adiponectin/leptin ratio and osteocalcin was demonstrated. Further, both lean and body fat mass were predictors of osteocalcin. Negative associations between leptin with osteocalcin, adiponectin with Beta CTX-collagen, and visceral fat with adiponectin were observed. Conclusions: It is possible to conclude that the inflammatory state can negatively influence the bone turnover markers in obese adolescents. In addition, the interdisciplinary weight loss treatment improved the inflammatory state and body composition in obese adolescents. Therefore, the present findings should be considered in clinical practice.
local.identifier.orcidhttps://orcid.org/0000-0001-6132-4349
local.identifier.orcidhttps://orcid.org/0000-0003-0187-6402
local.identifier.orcidhttps://orcid.org/0000-0002-8684-7290
local.identifier.orcidhttps://orcid.org/0000-0001-9038-2185
local.identifier.orcidhttps://orcid.org/0000-0003-0748-7141
local.identifier.orcidhttps://orcid.org/0000-0003-2315-5980
local.identifier.orcidhttps://orcid.org/0000-0003-0834-904X
local.identifier.orcidhttp://orcid.org/0000-0002-3804-8865
local.identifier.orcidhttps://orcid.org/0000-0003-3896-2208
local.identifier.orcidhttps://orcid.org/0000-0001-7675-7470
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE ESPORTES
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/aem/a/8ffB8dr5SfVNSFpmZPFWHWQ/abstract/?lang=en

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