Simultaneous occurrence of epstein-barr virus (EBV) in periodontal pockets and in oral squamous cell carcinoma: a cross-sectional study

Página do item simplificado
dc.creatorHumberto Jácome-Santos
dc.creatorRicardo Alves de Mesquita
dc.creatorSérgio de Melo Alves-Junior
dc.creatorNaira da Silva e Silva
dc.creatorRenata Gonçalves Resende
dc.creatorHelder Henrique Costa Pinheiro
dc.creatorLuiz Fernando Almeida Machado
dc.creatorGuilherme de Souza Silva
dc.creatorIgor Brasil-Costa
dc.creatorFernando de Oliveira Costa
dc.creatorAna Cláudia Braga Amoras-Alves
dc.date.accessioned2024-07-03T17:47:52Z
dc.date.accessioned2025-09-09T00:37:27Z
dc.date.available2024-07-03T17:47:52Z
dc.date.issued2021-11-16
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1007/s00784-021-04258-z
dc.identifier.issn1436-3771
dc.identifier.urihttps://hdl.handle.net/1843/69622
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofClinical Oral Investigations
dc.rightsAcesso Restrito
dc.subjectSquamous cell carcinoma of head and neck
dc.subjectHerpesvirus 4, human
dc.subjectPeriodontal pocket
dc.subjectNeoplasms
dc.subjectPeriodontitis
dc.subjectDNA, viral
dc.subject.otheroral squamous cell carcinoma acesso restrito Simultaneous occurrence of epstein-barr virus (ebv) in periodontal pockets and in oral squamous cell carcinoma: a cross-sectional study busca dia 02/07/2024
dc.subject.otherEpstein-Barr vírus Keywords: Epstein-Barr virus; Oral squamous cell carcinoma; Periodontal pocket, Cancer; Periodontitis.
dc.subject.otherPeriodontal pockets
dc.subject.othercross-sectional study Clinical oral investigations periódico
dc.titleSimultaneous occurrence of epstein-barr virus (EBV) in periodontal pockets and in oral squamous cell carcinoma: a cross-sectional study
dc.typeArtigo de periódico
local.citation.epage2815
local.citation.spage2807
local.citation.volume26
local.description.resumoObjectives: This study aimed to investigate the detection of Epstein-Barr virus (EBV) in oral squamous cell carcinoma (OSCC) and to verify the concordance of EBV-DNA frequency in subgingival sites and in the OSCC. Methods: A cross-sectional study with 30 OSCC patients, aged from 44 to 88 years old, was conducted. Samples were collected in subgingival sites and at the OSCC, then submitted to DNA isolation, qPCR, and genotyping. Descriptive statistic was performed to report the frequency of EBV-DNA in all samples, and McNemar test was applied to verify the concordance among the EBV-DNA frequency in both sites. Results: The individuals presented 62 years old in average, and the majority were male (66.6%). EBV-DNA was detected in 56.7% OSCC lesions. Among the subgroup of 19 dentate individuals, high concordance (73.7%) in both EBV-DNA detection and the absence in subgingival sites and OSCC was observed, and it was statistically significant (p < 0.05). Conclusions: We report the notable occurrence of EBV-DNA in OSCC; also, the presence of EBV in periodontal sites may contribute to find it in OSCC, although the possible contribution of EBV in the OSCC remains to be investigated. Clinical relevance: The identification of this easily accessible site of EBV latent infection may help to improve the patient's quality of life by maintenance of oral/periodontal health condition and preventing further possible disorders related to the virus, and also encourages new approaches for investigating EBV, periodontitis, and OSCC.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s00784-021-04258-z

Arquivos

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG