Mechanisms underlying chemotherapy-associated mucositis: the role of inflammatory mediators and potential therapeutic targets

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dc.creatorZelia Menezes Garcia
dc.creatorRaquel Duque do Nascimento Arifa
dc.creatorCaio Tavares Fagundes
dc.creatorDanielle da Glória de Souza
dc.date.accessioned2023-07-14T22:28:55Z
dc.date.accessioned2025-09-08T23:56:26Z
dc.date.available2023-07-14T22:28:55Z
dc.date.issued2018
dc.identifier.doihttps://doi.org/10.33590/emjgastroenterol/10310983.
dc.identifier.issn2054-6203
dc.identifier.urihttps://hdl.handle.net/1843/56322
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofEuropean Medical Journal Gastroenterology
dc.rightsAcesso Aberto
dc.subjectQuimioterapia
dc.subjectSistema gastrointestinal - Doenças
dc.subject.otherChemotherapy
dc.subject.otherMucositis
dc.subject.otherGastrointestinal
dc.titleMechanisms underlying chemotherapy-associated mucositis: the role of inflammatory mediators and potential therapeutic targets
dc.typeArtigo de periódico
local.citation.epage91
local.citation.issue1
local.citation.spage82
local.citation.volume7
local.description.resumoChemotherapy-induced mucositis is a common, often severe, side effect experienced by cancer patients during their treatment, which is a major challenge for successful anticancer therapy. As chemotherapy regimens evolve to include more efficacious agents, mucositis is increasingly becoming a major cause of dose-limiting toxicity and merits further investigation. This condition is characterised by both inflammation and loss of cells from the epithelial barrier of the gastrointestinal tract. This article reviews the current understanding of the inflammatory mechanisms behind chemotherapy’s toxic effect on the gastrointestinal tract and provides evidence that inflammation is a key factor behind gastrointestinal toxicity of chemotherapy. The authors discuss potential therapeutic targets that can contribute to mucositis treatment and prevention.
local.identifier.orcidhttps://orcid.org/0000-0002-1600-0289
local.identifier.orcidhttps://orcid.org/0000-0003-3432-0769
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.emjreviews.com/gastroenterology/article/editors-pick-mechanisms-underlying-chemotherapy-associated-mucositis-the-role-of-inflammatory-mediators-and-potential-therapeutic-targets/

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