Expression of matrix metalloproteinases 2 and 9 in replanted teeth with external root resorption: a cross-sectional study

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dc.creatorThiago César da Silva Lima
dc.creatorRoberta Gabriela Amaro
dc.creatorLetícia Canhestro Machado dos Santos
dc.creatorSylvia Cury Coste
dc.creatorEduardo Fernandes e Silva
dc.creatorDaniela Augusta Barbato-Ferreira
dc.creatorEnrico Antônio Colosimo
dc.creatorTarcília Aparecida da Silva
dc.creatorJuliana Vilela Bastos
dc.date.accessioned2025-05-05T23:10:32Z
dc.date.accessioned2025-09-08T23:35:00Z
dc.date.available2025-05-05T23:10:32Z
dc.date.issued2021-09
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.archoralbio.2021.105194
dc.identifier.issn1879-1506
dc.identifier.urihttps://hdl.handle.net/1843/82040
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofArchives of Oral Biology
dc.rightsAcesso Restrito
dc.subjectMatrix metalloproteinase 2
dc.subjectMatrix metalloproteinase 9
dc.subjectMatrix metalloproteinases
dc.subjectTooth avulsion
dc.subjectTooth replantation
dc.subjectTissue inhibitor of metalloproteinase-2
dc.subjectEvaluation study
dc.subject.otherExternal root resorption
dc.subject.otherMMP-2
dc.subject.otherMMP-9
dc.subject.otherMatrix metalloproteinase
dc.subject.otherTooth avulsion
dc.subject.otherTooth replantation
dc.titleExpression of matrix metalloproteinases 2 and 9 in replanted teeth with external root resorption: a cross-sectional study
dc.typeArtigo de periódico
local.citation.epage8
local.citation.spage1
local.citation.volume129
local.description.resumoObjective: To evaluate matrix metalloproteinase (MMP) expression in replanted permanent teeth with external root resorption (ERR). Design: The present cross-sectional study included 42 patients with replanted permanent teeth, presenting with progressive forms of ERR, and referred for extraction according to the rehabilitation treatment plan or due to root fractures. The control group consisted of 12 healthy premolars, from 5 patients with good periodontal health and no radiographic evidence of root resorption, referred for extraction for orthodontic reasons. Root fragments were processed soon after extraction, and the supernatant was collected to measure matrix metalloproteinase 2/tissue inhibitor of metalloproteinase 2 (MMP-2/TIMP-2) and matrix metalloproteinase 9/tissue inhibitor of metalloproteinases 2 (MMP-9/TIMP-2) complexes through a double-ligand enzyme-linked immunosorbent assay (ELISA). Results: Case groups with external inflammatory root resorption (EIRR) or external replacement root resorption (ERRR) showed significantly higher levels of MMP-2/TIMP-2 and MMP-9/TIMP-2 complexes than the control group. Additionally, comparisons between the case groups demonstrated that the MMP-2/TIMP-2 complex also had significantly higher levels in the ERRR group (p < 0.001). Conclusions: Our results suggest that MMP-2 and MMP-9 participate in the pathobiology of both types of ERR. In addition, the higher levels of MMP-2/TIMP-2 complex in the ERRR group support common modulation mechanisms with physiological bone turnover.
local.identifier.orcidhttps://orcid.org/0000-0002-2747-7736
local.identifier.orcidhttps://orcid.org/0000-0003-3344-1585
local.identifier.orcidhttps://orcid.org/0000-0002-5381-8979
local.identifier.orcidhttps://orcid.org/0000-0002-1699-1895
local.identifier.orcidhttps://orcid.org/0000-0001-8705-4674
local.identifier.orcidhttps://orcid.org/0000-0001-9623-7835
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.departmentICX - DEPARTAMENTO DE ESTATÍSTICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0003996921001576?via%3Dihub

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