Constituents from roots of Maytenus distichophylla, antimicrobial activity and toxicity for cells and Caenorhabditis elegans

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dc.creatorShirley Alejandra Torres Morales
dc.creatorViviane de Souza Alves
dc.creatorSidney Augusto Vieira Filho
dc.creatorRafael Cesar Gonçalves Pereira
dc.creatorLucienir Pains Duarte
dc.creatorGrasiely Faria de Sousa
dc.creatorDjalma Menezes de Oliveira
dc.creatorFernanda Cristina Gontijo Evangelista
dc.creatorAdriano de Paula Sabino
dc.creatorRoberta Oliveira Viana
dc.creatorMariana Guerra de Aguilar
dc.date.accessioned2022-11-09T23:19:31Z
dc.date.accessioned2025-09-08T23:27:33Z
dc.date.available2022-11-09T23:19:31Z
dc.date.issued2020
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.21577/0100-4042.20170591
dc.identifier.issn0100-4042
dc.identifier.urihttps://hdl.handle.net/1843/47108
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofQuímica Nova
dc.rightsAcesso Aberto
dc.subjectCelastraceae
dc.subjectTerpenios
dc.subjectMaytenus
dc.subjectLeucemia
dc.subjectCitotoxidade de mediação celular
dc.subject.otherCelastraceae
dc.subject.otherPentacyclic triterpenes
dc.subject.otherToxicity
dc.subject.otherK562 cells
dc.subject.otherTHP-1 cells
dc.subject.otherMaytenus distichophylla
dc.subject.otherLeukemia
dc.subject.otherCytotoxicity
dc.titleConstituents from roots of Maytenus distichophylla, antimicrobial activity and toxicity for cells and Caenorhabditis elegans
dc.typeArtigo de periódico
local.citation.epage1073
local.citation.issue8
local.citation.spage1066
local.citation.volume43
local.description.resumoMaytenus distichophylla is a medicinal species used in Northeast of Brazil. The hexane (HE), chloroform (CE), ethyl acetate (EAE) and methanol (ME) extracts and compounds from its roots were evaluated for their protective activity against Staphylococcus aureus and Candida albicans. The cytotoxicity for chronic myeloid leukemia (K562), acute monocytic leukemia (THP-1), and peripheral blood mononuclear cells of normal individuals (PBMC) cells was established by MTT method using etoposide as standard. The in vivo toxicity of samples was determined using Caenorhabditis elegans model. From HE and CE were isolated: friedelan-3-one (1), b-sitosterol (2), 3-oxo-olean-9(11),12-diene (3), a mixture of pristimerin (4) and 11a-hydroxylup-20(29)-en-3-one (5), 30-hydroxylup-20(29)-en-3-one (6), friedelane-3,7-dione (7), tingenone (8) and triacylglycerol (9). The structures of 1-9 were confirmed by spectral data. All samples reduced the viability of S. aureus and present no effect against C. albicans. The HE, CE, mixture of 4/5 and 8 reduced 75% of S. aureus viability. Cytotoxic effect for K562 and THP-1 cells was caused by compounds 1, 2 and 8. All samples displayed selectivity for leukemic cells and low toxicity to PBMC cells, suggesting their potential as anticancer agents. Extracts and compounds were non-toxic to L1 larvae of C. elegans. However, most of them reduced significantly young adult worm’s survival, being considered as potential nematicides.
local.identifier.orcidhttps://orcid.org/0000-0002-8885-6625
local.identifier.orcidhttps://orcid.org/0000-0001-7425-2604
local.identifier.orcidhttps://orcid.org/0000-0002-0625-6619
local.identifier.orcidhttps://orcid.org/0000-0002-8171-8035
local.identifier.orcidhttps://orcid.org/0000-0001-6454-8946
local.identifier.orcidhttps://orcid.org/0000-0003-1600-7621
local.identifier.orcidhttps://orcid.org/0000-0002-7765-9853
local.identifier.orcidhttps://orcid.org/0000-0003-4682-397X
local.identifier.orcidhttps://orcid.org/0000-0001-8562-8689
local.identifier.orcidhttps://orcid.org/0000-0003-1014-8132
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/qn/a/wsCkNh5MJdfJC5wXSngZqbJ/#

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