Anti-inflammatory potential of a carvedilol gel in the pulpal tissue of rats after dental bleaching: a histopathological evaluation

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dc.creatorLidiane Mendes Louzada
dc.creatorAndré Luiz Fraga Briso
dc.creatorFrancine Benetti
dc.creatorLetícia Vieira
dc.creatorRogério de Castilho Jacinto
dc.creatorElói Dezan-Júnior
dc.creatorLuciano Tavares Ângelo Cintra
dc.date.accessioned2022-10-03T19:04:31Z
dc.date.accessioned2025-09-08T23:24:45Z
dc.date.available2022-10-03T19:04:31Z
dc.date.issued2019-01-28
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1111/jicd.12401
dc.identifier.issn20411618
dc.identifier.urihttps://hdl.handle.net/1843/45900
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Investigative and Clinical Dentistry
dc.rightsAcesso Restrito
dc.subjectCarvedilol
dc.subjectHydrogen peroxide
dc.subjectInflammation
dc.subjectDental pulp cavity
dc.subjectTooth bleaching
dc.subject.otherCarvedilol
dc.subject.otherHydrogen peroxide
dc.subject.otherInflammation
dc.subject.otherPulp
dc.subject.otherTooth bleaching
dc.titleAnti-inflammatory potential of a carvedilol gel in the pulpal tissue of rats after dental bleaching: a histopathological evaluation
dc.typeArtigo de periódico
local.citation.epage8
local.citation.issue2
local.citation.spage1
local.citation.volume10
local.description.resumoAim: Carvedilol is an antioxidant that decreases inflammation in periodontitis. The hydrogen peroxide (H2 O2 ) of bleaching gel causes inflammation and necrosis of the dental pulp. In the present study, we evaluated the anti-inflammatory potential of carvedilol in the pulp of rats after bleaching. Methods: The right upper molars of rats received 35% H2 O2 (1× 30 minutes), and the left upper molars were used as the control. Half of the rats received carvedilol gel (1× 10 minutes), forming the following groups: bleached, bleached followed by carvedilol (bleached+carvedilol), and control. After 2 and 30 days (N = 7 hemi-maxillae/group), the rats were killed for histological evaluation, and statistical tests were performed (P < 0.05). Results: After 2 days, the bleached group showed necrosis in the occlusal third of the coronal pulp, and in the bleached+carvedilol group, severe inflammation (P > 0.05), both different from the control (P < 0.05). In the middle third, the bleached group showed severe inflammation, and the bleached+carvedilol group showed moderate inflammation (P > 0.05), with the only difference between the bleached and control groups (P < 0.05). In the cervical third, the bleached group showed moderate inflammation, and the bleached+carvedilol group showed mild inflammation (P > 0.05). The difference again was only between the bleached and control groups (P < 0.05). At 30 days, there was no inflammation and a marked amount of tertiary dentin in bleached teeth (P > 0.05). Conclusion: Carvedilol gel has the potential of minimizing H2 O2 damage, especially in deep regions of the dental pulp of rats after bleaching.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jicd.12401

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