Photophysical, photodynamical, redox properties and BSA interactions of novel isomeric tetracationic peripheral palladium(II)-bipyridyl porphyrins

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dc.creatorFabiano da Silveira Santos
dc.creatorCarolina Hahn da Silveira
dc.creatorFábio Souza Nunes
dc.creatorDaniele Cristina Ferreira
dc.creatorHenrique Fernandes Vieira Victória
dc.creatorKlaus Wilhelm Heinrich Krambrock
dc.creatorOtávio Augusto Chaves
dc.creatorFabiano Severo Rodembusch
dc.creatorBernardo Almeida Iglesias
dc.date.accessioned2022-11-11T13:15:26Z
dc.date.accessioned2025-09-09T00:15:23Z
dc.date.available2022-11-11T13:15:26Z
dc.date.issued2020
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1039/d0dt01063d
dc.identifier.issn14779234
dc.identifier.urihttps://hdl.handle.net/1843/47171
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofDalton Transactions
dc.rightsAcesso Restrito
dc.subjectPorphyrins
dc.subject.otherBSA interactions
dc.subject.otherIsomeric tetra-cationic porphyrins
dc.titlePhotophysical, photodynamical, redox properties and BSA interactions of novel isomeric tetracationic peripheral palladium(II)-bipyridyl porphyrins
dc.typeArtigo de periódico
local.citation.epage16295
local.citation.issue45
local.citation.spage16278
local.citation.volume49
local.description.resumoNew isomeric tetra-cationic porphyrins containing peripheral [Pd(bpy)Cl]+ units attached to pyridyl substituents were synthesized and fully characterized. The porphyrins present an intense Soret band located in the blue spectral region and an additional four weaker red-shifted Q bands in the visible spectral region (about 500–700 nm). The obtained Strickler–Berg parameters indicate fully spin and symmetry allowed transitions for all the observed absorption bands. Both porphyrins present two fluorescence emission bands, an intense one located around 650 nm and an additional weak red-shifted emission at ∼710 nm. Fluorescence decay time profiles were obtained showing bi-exponential decay. The interaction of the porphyrins with bovine serum albumin (BSA) was studied in detail by a fluorescence quenching method and molecular docking analysis. In addition, the photodynamical activity of the porphyrins in the photooxidation of BSA was determined and compared with the light-induced formation of reactive oxygen species (ROS) by electron paramagnetic resonance (EPR) allied with the spin trapping method. The results show that the Pd(II)-bypyridyl tetra-cationic porphyrins are promising candidates for the photooxidation of biological substrates used in photodynamic therapy (PDT).
local.identifier.orcidhttps://orcid.org/0000-0003-4130-2083
local.identifier.orcidhttps://orcid.org/0000-0002-4289-7368
local.identifier.orcidhttps://orcid.org/0000-0002-5988-6016
local.identifier.orcidhttps://orcid.org/0000-0001-9523-1298
local.identifier.orcidhttps://orcid.org/0000-0002-4846-2189
local.identifier.orcidhttps://orcid.org/0000-0002-7562-0285
local.identifier.orcidhttps://orcid.org/0000-0001-6211-7659
local.identifier.orcidhttps://orcid.org/0000-0001-6528-2318
local.identifier.orcidhttps://orcid.org/0000-0002-4039-6316
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.initialsUFMG
local.url.externahttps://pubs.rsc.org/en/content/articlelanding/2020/DT/D0DT01063D

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