Tunable magnetothermal properties of cobalt-doped magnetite-carboxymethylcellulose ferrofluids: smart nanoplatforms for potential magnetic hyperthermia applications in cancer therapy

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dc.creatorAlice Gameiro Leonel
dc.creatorAlexandra Ancelmo Piscitelli Mansur
dc.creatorSandhra Maria de Carvalho
dc.creatorLuis Eugenio Fernandez Outon
dc.creatorJose Domingos Ardisson
dc.creatorKlaus Wilhelm Heinrich Krambrock
dc.creatorHerman Sander Mansur
dc.date.accessioned2025-02-26T11:18:55Z
dc.date.accessioned2025-09-09T01:13:11Z
dc.date.available2025-02-26T11:18:55Z
dc.date.issued2021
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipFINEP - Financiadora de Estudos e Projetos, Financiadora de Estudos e Projetos
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1039/d0na00820f
dc.identifier.issn2516-0230
dc.identifier.urihttps://hdl.handle.net/1843/80446
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofNanoscale Advances
dc.rightsAcesso Aberto
dc.subjectMagnetita
dc.subjectNanopartículas
dc.subjectCâncer
dc.subject.otherMagnetite nanoparticles
dc.subject.otherMagnetite nanoparticles
dc.subject.otherCancer
dc.subject.otherCancer
dc.titleTunable magnetothermal properties of cobalt-doped magnetite-carboxymethylcellulose ferrofluids: smart nanoplatforms for potential magnetic hyperthermia applications in cancer therapy
dc.typeArtigo de periódico
local.citation.epage1046
local.citation.issue4
local.citation.spage1029
local.citation.volume3
local.description.resumoMagnetite nanoparticles are one of the most promising ferrofluids for hyperthermia applications due to the combination of unique physicochemical and magnetic properties. In this study, we designed and produced superparamagnetic ferrofluids composed of magnetite (Fe3O4, MION) and cobalt-doped magnetite (Cox-MION, x = 3, 5, and 10% mol of cobalt) nanoconjugates through an eco-friendly aqueous method using carboxymethylcellulose (CMC) as the biocompatible macromolecular ligand. The effect of the gradual increase of cobalt content in Fe3O4 nanocolloids was investigated in-depth using XRD, XRF, XPS, FTIR, DLS, zeta potential, EMR, and VSM analyses. Additionally, the cytotoxicity of these nanoconjugates and their ability to cause cancer cell death through heat induction were evaluated by MTT assays in vitro. The results demonstrated that the progressive substitution of Co in the magnetite host material significantly affected the magnetic anisotropy properties of the ferrofluids. Therefore, Co-doped ferrite (CoxFe(3−x)O4) nanoconjugates enhanced the cell-killing activities in magnetic hyperthermia experiments under alternating magnetic field performed with human brain cancer cells (U87). On the other hand, the Co-doping process retained the pristine inverse spinel crystalline structure of MIONs, and it has not significantly altered the average nanoparticle size (ca.∼7.1 ± 1.6 nm). Thus, the incorporation of cobalt into magnetite-polymer nanostructures may constitute a smart strategy for tuning their magnetothermal capability towards cancer therapy by heat generation.
local.identifier.orcidhttps://orcid.org/0000-0002-8798-4182
local.identifier.orcidhttps://orcid.org/0000-0003-1526-2508
local.identifier.orcidhttps://orcid.org/0000-0001-6665-8647
local.identifier.orcidhttps://orcid.org/0000-0003-3264-337X
local.identifier.orcidhttps://orcid.org/0000-0002-7562-0285
local.identifier.orcidhttps://orcid.org/0000-0002-3032-495X
local.publisher.countryBrasil
local.publisher.departmentENG - DEPARTAMENTO DE ENGENHARIA METALÚRGICA
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.initialsUFMG
local.url.externahttps://pubs.rsc.org/en/content/articlelanding/2021/na/d0na00820f

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