Prospective and randomized evaluation of chronos and bio-oss in human maxillary sinuses: histomorphometric and immunohistochemical assignment for runx 2, vascular endothelial growth factor, and osteocalcin

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dc.creatorJoão Paulo Bonardi
dc.creatorRodrigo dos Santos Pereira
dc.creatorFernanda Brasil Daura Jorge Boos Lima
dc.creatorLeonardo Perez Faverani
dc.creatorGeraldo Luiz Griza
dc.creatorRoberta Okamoto
dc.creatorEduardo Hochuli-Vieira
dc.date.accessioned2024-03-25T18:48:45Z
dc.date.accessioned2025-09-09T00:45:20Z
dc.date.available2024-03-25T18:48:45Z
dc.date.issued2018-02
dc.identifier.doihttps://doi.org/10.1016/j.joms.2017.09.020
dc.identifier.issn02782391
dc.identifier.urihttps://hdl.handle.net/1843/66470
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of oral and maxillofacial surgery
dc.rightsAcesso Restrito
dc.subjectBone transplantation
dc.subjectPhosphates
dc.subjectBone and bones
dc.subjectMaxillary sinus
dc.subject.otherperiódico: Journal of oral and maxillofacial surgery acesso restrito assunto Bone Transplantation busca dia 21/02/2024 fao clínica Prospective and randomized evaluation of chronos and bio-oss in human maxillary sinuses: histomorphometric and immunohistochemical assignment for runx 2, vascular endothelial growth factor, and osteocalcin
dc.titleProspective and randomized evaluation of chronos and bio-oss in human maxillary sinuses: histomorphometric and immunohistochemical assignment for runx 2, vascular endothelial growth factor, and osteocalcin
dc.typeArtigo de periódico
local.citation.epage335
local.citation.issue2
local.citation.spage325
local.citation.volume76
local.description.resumoPurpose: The aim of this study was to compare ChronOS (β-tricalcium phosphate), Bio-Oss, and their addition to an autogenous bone graft in a 1:1 ratio in human maxillary sinus bone augmentation. Materials and methods: Thirty maxillary sinuses were divided in 5 groups: group 1 included 6 maxillary sinuses grafted with autogenous bone graft alone; group 2 included 6 maxillary sinuses grafted with ChronOS; group 3 included 6 maxillary sinuses grafted with ChronOS and autogenous bone graft in a 1:1 ratio; group 4 included 6 maxillary sinuses grafted with Bio-Oss; and group 5 included 6 maxillary sinuses grafted with Bio-Oss and autogenous bone graft in a 1:1 ratio. The number of samples for each group was determined by the statistical power test. Results: The median areas of new bone formation in groups 1, 2, 3, 4, and 5 were 121,917.0, 83,787.0, 99,295.0, 65,717.0, and 56,230.0 μm2, respectively. Statistically significant differences were found between groups 3 and 5, groups 1 and 4, and groups 1 and 5 (P < .05). The median areas of remaining biomaterial were 2,900.5, 5,291.0, 2,662.0, 56,258.5, and 64,753.5 μm2 in groups 1, 2, 3, 4 and 5, respectively. Statistically significant differences occurred between groups 1 and 5, groups 3 and 5, and groups 2 and 5 (P < .05). Areas of connective tissue were 67,829.0 ± 22,984.6 μm2 in group 1, 97,445.9 ± 18,983.3 μm2 in group 2, 88,256.0 ± 21,820.5 μm2 in group 3, 65,501.8 ± 6,297.6 in group 4, and 70,203.2 ± 13,421.3 μm2 in group 5. Conclusions: ChronOS combined with autogenous bone graft presented a behavior similar to that of autogenous bone graft alone. However, the groups treated with Bio-Oss showed immuno-labeling results indicating maturation of grafted bone.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0278239117312442?via%3Dihub

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