Synthesis, in vitro and in vivo anti-trypanosoma cruzi and toxicological activities of nitroaromatic schiff bases

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dc.creatorTamires Cunha Almeida
dc.creatorLuis Henrique Gonzaga Ribeiro
dc.creatorLuzia Braga Ferreira dos Santos
dc.creatorCleiton Moreira da Silva
dc.creatorRenata Tupinambá Branquinho
dc.creatorMarta de Lana
dc.creatorFernanda Ramos Gadelha
dc.creatorÂngelo de Fátima
dc.date.accessioned2024-09-24T18:28:00Z
dc.date.accessioned2025-09-09T00:09:48Z
dc.date.available2024-09-24T18:28:00Z
dc.date.issued2018
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.biopha.2018.09.176
dc.identifier.issn0753-3322
dc.identifier.urihttps://hdl.handle.net/1843/76850
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBiomedicine & Pharmacotherapy
dc.rightsAcesso Aberto
dc.subjectSchiff, Bases de
dc.subjectTripanossomo
dc.subjectChagas, Doença de
dc.subject.otherSchiff bases
dc.subject.otherAldimines
dc.subject.otherTrypanosoma cruzi
dc.subject.otherTrypanocidal activity
dc.subject.otherChagas disease
dc.subject.otherProtozoan parasite
dc.titleSynthesis, in vitro and in vivo anti-trypanosoma cruzi and toxicological activities of nitroaromatic schiff bases
dc.typeArtigo de periódico
local.citation.epage1711
local.citation.spage1703
local.citation.volume108
local.description.resumoChagas disease is a major health problem not only in Latin America but also in Europe and North America due to the spread of this disease into nonendemic areas. In terms of global burden, this major tropical infection is considered to be one of the most neglected diseases, and there are currently only two available chemotherapies: benznidazole and nifurtimox. Unfortunately, although these chemotherapies are beneficial in the acute phase of the disease, benznidazole and nifurtimox lead to significant side effects, including hepatitis and neurotoxicity. Therefore, the search for and development of more effective, safe and inexpensive anti-Trypanosoma cruzi drugs are required. In this work, a series of 10 nitroaromatic Schiff bases bearing different (nitro) aromatic rings-was synthesized. Subsequently, the in vitro and in vivo anti-T. cruzi activities of the Schiff bases were investigated, as well as the in vivo toxicity and the biological effects. The basic structure of the most promising in vivo Schiff base, 10 would be useful in the synthesis of new compounds for Chagas disease treatment.
local.identifier.orcidhttps://orcid.org/0000-0002-5584-3609
local.identifier.orcidhttps://orcid.org/0000-0001-6592-3971
local.identifier.orcidhttps://orcid.org/0000-0001-9913-8971
local.identifier.orcidhttps://orcid.org/0000-0001-7907-5651
local.identifier.orcidhttps://orcid.org/0000-0002-1075-8830
local.identifier.orcidhttps://orcid.org/0000-0003-2344-5590
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0753332218350078?via%3Dihub

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