Síntese de derivados glicosiltriazólicos de paclitaxel como potenciais antitumorais

Abstract

Neoplasias are associated with an uncontrolled growth of cells, resulting from risk factors called carcinogenic agents, being one of the biggest causes of death in the world. The high extent of the disease and the variety of tumors identified require a continued investment in new therapeutic strategies, including the development of new chemotherapeutic agents. There are reports of glycosyloxy derivatives of paclitaxel, exhibiting high aqueous solubility and relatively in vitro cytotoxic activity comparing to paclitaxel. Based on these data, a number of glycosyltriazole derivatives of paclitaxel were planned and synthesized. Between intermediates and products, nineteen substances were obtained, nine of which were unpublished, with yields mostly moderate or good. Four planned derivatives were not obtained and one without the complete confirmation of obtaining. The compounds prepared will be used in future biological assays to evaluate their cytotoxic potential and to target tumor tissue and the evaluation of physicochemical characteristics.