Effects of tobacco on the DNA of smokers and non-smokers affected by OSCC - systematic review and meta-analysis

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dc.creatorLauren Frenzel Schuch
dc.creatorKarolina Skarlet Silva Viana
dc.creatorJosé Alcides Almeida de Arruda
dc.creatorLucas Guimarães Abreu
dc.creatorMaria Cássia Ferreira de Aguiar
dc.creatorVanessa Fátima Bernardes
dc.date.accessioned2024-08-22T20:50:31Z
dc.date.accessioned2025-09-09T00:11:06Z
dc.date.available2024-08-22T20:50:31Z
dc.date.issued2023-01-06
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1590/1807-3107bor-2023.vol37.0008
dc.identifier.issn1807-3107
dc.identifier.urihttps://hdl.handle.net/1843/74733
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBrazilian Oral Research
dc.rightsAcesso Aberto
dc.subjectDNA damage
dc.subjectHead and neck neoplasms
dc.subjectMeta-analysis
dc.subjectMouth neoplasms
dc.subjectSystematic review
dc.subjectTobacco smoking
dc.subjectPTEN phosphohydrolase
dc.subjectCarcinoma, squamous cell
dc.subjectGenes
dc.subjectProteins
dc.subject.otherDNA damage
dc.titleEffects of tobacco on the DNA of smokers and non-smokers affected by OSCC - systematic review and meta-analysis
dc.typeArtigo de periódico
local.citation.epage16
local.citation.issue8
local.citation.spage1
local.citation.volume37 Brazilian Oral Research
local.description.resumoScientific evidence about genetic and molecular changes in oral squamous cell carcinoma (OSCC) among smokers and non-smokers is inconclusive. This systematic review and meta-analysis assessed the effects of tobacco on the DNA of individuals with OSCC based on protein mutations. Electronic searches were conducted on PubMed, Ovid, Web of Science, and Scopus to identify observational studies published up to January/2022. The Joanna Briggs Institute tool was used for the critical appraisal of studies. The certainty of the evidence was evaluated. Twenty-three studies assessing 4,060 individuals (2,967 smokers vs. 1,093 non-smokers) were included in this review. Fifteen groups of proteins/genes were investigated. Analysis of the quality of articles revealed low risk of bias in most studies. The certainty of the evidence was very low. The meta-analysis confirmed no significant difference between smokers and non-smokers with respect to damage to GSTM1 (OR: 0.60; 95%CI: 0.30–1.18), GSTT1 (OR: 1.18; 95%CI:0.49–2.83), hydrolase proteins (Ku70 and Ku80) (OR: 0.74; 95%CI: 0.18–3.05), and transferase proteins (GSTM1, GSTT1, GSTM3) (OR: 0.74; 95%CI: 0.47–1.18). Most of the studies included showed that smokers are more likely to exhibit genetic instability. However, the meta-analysis revealed that smokers do not necessarily have more genetic alterations in the DNA than non-smokers.
local.identifier.orcidhttps://orcid.org/0000-0001-9273-376X
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/bor/a/bYtHcQCh7j7PRBCkBj3RpYh/#

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