Embryonal rhabdomyosarcoma (botryoid subtype) affecting the buccal mucosa

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dc.creatorJohn Lennon Silva Cunha
dc.creatorFrancisco de Assis Almeida Lima-Júnior
dc.creatorWilson Déda Gonçalves Júnior
dc.creatorThiago de Santana Santos
dc.creatorEricka Janine Dantas da Silveira
dc.creatorSílvia Ferreira de Sousa
dc.creatorRicardo Luiz Cavalcanti de Albuquerque Junior
dc.date.accessioned2025-07-08T20:13:57Z
dc.date.accessioned2025-09-09T01:11:53Z
dc.date.available2025-07-08T20:13:57Z
dc.date.issued2019-12
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1007/s12105-018-0957-8
dc.identifier.issn1936-0568
dc.identifier.urihttps://hdl.handle.net/1843/83425
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofHead and Neck Pathology
dc.rightsAcesso Restrito
dc.subjectRadiotherapy
dc.subjectHead and neck neoplasms
dc.subjectRhabdomyosarcoma
dc.subjectDesmin
dc.subjectMyogenin
dc.subjectKi-67 antigen
dc.subjectConsolidation chemotherapy
dc.subjectImmunohistochemistry
dc.subjectRhabdomyosarcoma, embryonal
dc.subjectCell proliferation
dc.subject.otherHead and neck neoplasms
dc.subject.otherPediatric rhabdomyosarcoma
dc.subject.otherRadiotherapy
dc.subject.otherRhabdomyosarcoma
dc.titleEmbryonal rhabdomyosarcoma (botryoid subtype) affecting the buccal mucosa
dc.typeArtigo de periódico
local.citation.epage676
local.citation.issue4
local.citation.spage671
local.citation.volume13
local.description.resumoRhabdomyosarcoma (RMS) is a rare oral malignant soft tissue tumor whose pathological features may influence the clinical behavior, treatment and prognosis of the lesion. We report a case of a 13-year-old female patient, presenting an asymptomatic polypoid swelling in the left buccal mucosa that was approximately 2.5 cm in diameter and 3 months evolution. The presumptive diagnosis was fibrous hyperplasia and an excisional biopsy was carried out. Pathologic analysis revealed proliferation of predominantly ovoid cells, with eosinophilic cytoplasm and pleomorphic nuclei, arranged in subepithelial cambium layer. The mucosal surface presented a papillary-verrucous appearance. Immunohistochemical analysis revealed intense positivity for desmin, myogenin and Ki-67. The diagnosis was of embryonal RMS (botryoid variant). The patient was subjected to complementary chemotherapy and radiotherapy, with no evidence of recurrence or metastatic disease after 12 months follow-up. A discussion on the clinical, histopathological, immunohistochemical and therapeutic aspects of botryoid RMS will be provided.
local.identifier.orcidhttps://orcid.org/0000-0002-0679-8485
local.identifier.orcidhttps://orcid.org/0000-0003-2128-0147
local.identifier.orcidhttps://orcid.org/0000-0001-7820-4749
local.identifier.orcidhttps://orcid.org/0000-0003-4444-7632
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s12105-018-0957-8

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