Hydroalcoholic extract of Solanum lycocarpum A. St. Hil. (Solanaceae) leaves improves alloxan-induced diabetes complications in mice

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dc.creatorVictor Hugo Dantas Guimarães
dc.creatorJéssica Nayara Basilio Silva
dc.creatorDaniela Fernanda de Freitas
dc.creatorOtávio Cardoso Filho
dc.creatorLuiz Henrique da Silveira
dc.creatorBarbhara Mota Marinho
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorGeraldo Aclécio Melo
dc.creatorSérgio Henrique Sousa Santos
dc.date.accessioned2023-04-26T12:16:36Z
dc.date.accessioned2025-09-09T00:02:52Z
dc.date.available2023-04-26T12:16:36Z
dc.date.issued2021-01-28
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.identifier.doi10.2174/0929866528999210128205817
dc.identifier.issn1875-5305
dc.identifier.urihttps://hdl.handle.net/1843/52496
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofProtein & Peptide Letters
dc.rightsAcesso Restrito
dc.subjectDiabetes
dc.subjectPlantas medicinais
dc.subjectMedicina popular
dc.subjectAloxana
dc.subjectQuímica vegetal
dc.titleHydroalcoholic extract of Solanum lycocarpum A. St. Hil. (Solanaceae) leaves improves alloxan-induced diabetes complications in mice
dc.typeArtigo de periódico
local.citation.epage780
local.citation.issue7
local.citation.spage769
local.citation.volume28
local.description.resumoBackground: Solanum lycocarpum is a medicinal plant used in Brazil with hypoglycemic activity by its fruits use. However, the fruits production is restricted in some periods of the year, differently of leaves. Objective: to evaluate the effects of hydroalcoholic extracts of S. lycocarpum leaves in alloxan-induced diabetic mice. Methods: hydroalcoholic extract of S. lycocarpum was characterized by phytochemical and GCMS analysis. The Antidiabetic activity was assessed following treatment for 22 days with S. lycocarpum extract at 125, 250, and 500 mg/kg. Bodyweight, water, and food intake, glycemia, biochemical parameters, anatomy-histopathology of the pancreas, liver and kidney, and expression of target genes were analyzed. In addition, oral acute toxicity was evaluated. Results: animals treated showed a significant reduction (p < 0.05) in glycemia following a dose of 125 mg/kg. Food intake remained similar for all groups. Decreased polydipsia symptoms were observed after treatment with 250 (p < 0.001) and 500 mg/kg (p < 0.01) compared with diabetic control, although normal rates were observed when 125 mg/kg was administered. A protective effect was also observed in the pancreas, liver, and kidneys, through the regeneration of the islets. Hypoglycemic activity can be attributed to myo-inositol, which stimulates insulin secretion, associated with α-tocopherol, which prevents damage from oxidative stress and apoptosis of β-pancreatic cells by an increased Catalase (CAT) and Glutathione peroxidase 4 (GPX4) mRNA expression. The toxicological test demonstrated safe oral use of the extract under the present conditions. Conclusion: hydroalcoholic extract of S. lycocarpum promotes the regulation of diabetes in the case of moderate glycemic levels, by decreasing glycemia and exerting protective effects on the islets.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.eurekaselect.com/article/113765

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