Chemical Profile, Toxicity, Anti-Acetylcholinesterase and Anti-microbial Activity of Essential Oil from Hyptis dilatata Leave

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dc.creatorPereira Almeida Sirley
dc.creatorAntonio a de Melo Filho
dc.creatorFernanda Guilhom Simplicio
dc.creatorM. G. Martins Regildo
dc.creatorJacqueline Aparecida Takahashi
dc.creatorVany P. Ferraz
dc.creatorAna Cristina G. Reis de Melo
dc.creatorPedro Tadei Wanderli
dc.date.accessioned2023-10-16T21:44:05Z
dc.date.accessioned2025-09-09T00:18:21Z
dc.date.available2023-10-16T21:44:05Z
dc.date.issued2018
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3303/CET1864046
dc.identifier.issn2283-9216
dc.identifier.urihttps://hdl.handle.net/1843/59489
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofChemical Engineering Transactions
dc.rightsAcesso Aberto
dc.subjectQuímica
dc.subjectProdutos de ação antimicrobiana
dc.subjectEssências e Óleos Essenciais
dc.subject.otherQuímica
dc.subject.otherProdutos de ação antimicrobiana
dc.subject.otherEssências e Óleos Essenciais
dc.titleChemical Profile, Toxicity, Anti-Acetylcholinesterase and Anti-microbial Activity of Essential Oil from Hyptis dilatata Leave
dc.typeArtigo de periódico
local.citation.epage276
local.citation.spage271
local.citation.volume64
local.description.resumoThe aim of this study was to evaluate the influence of seasonality on the chemical composition of the essential oil from Hyptis dilatata leaves, to perform biological activity assays such as antimicrobial, inhibition of acetylcholinesterase enzyme and to evaluate the toxicity of the essential oil using Artemia salina as indicator on the test. Hyptis dilatata leaves were collected in rainy and dry seasons, in the morning, in the afternoon and in the evening. It was extracted by hydrodistillation using the extractor of Clevenger condenser double Spell model. The essential oil analysis resulted in 22 chemical components. The major constituents of the dry and rainy periods were α-pinene (18.7% in the night and 12.9% in the afternoon), 3-carene (26.5% and 19.9% in the night), fenchone (43% and 33.7% in the morning) and β-caryophyllene 9.1% in the afternoon and 6.1% in the morning. The essential oil in vitro inhibited the acetylcholinesterase enzyme in 99.9% in the afternoon (rainy period) and 96.4% in the morning (dry period). Between the dry and rainy seasons, the lowest LC50 microbial activity in vitro was obtained for leaves collected during rainy season, in the morning period tested against the bacterium Staphylococcus aureus (LC50 78.1 mg mL-1). The cytotoxic activity of the essential oil of H. dilatata on Artemia salina showed LC50 results below 100 μg mL-1 and in the afternoon during the rainy period and at night in the dry period the results are above this value. Therefore, the chemical characterization and biological activities tests of essential oils showed promising results in the search for new active substances and the development of bioproducts of vegetable origin.
local.identifier.orcidhttps://orcid.org/0000-0002-8831-1609
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.aidic.it/cet/18/64/046.pdf

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