Loss of oral mucosal stem cell markers in oral submucous fibrosis and their reactivation in malignant transformation

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dc.creatorMohit Sharma
dc.creatorFelipe Paiva Fonseca
dc.creatorKeith Hunter
dc.creatorRaghu Radhakrishnan
dc.date.accessioned2024-01-19T19:08:21Z
dc.date.accessioned2025-09-08T23:25:11Z
dc.date.available2024-01-19T19:08:21Z
dc.date.issued2020-08-21
dc.identifier.doihttps://doi.org/10.1038/s41368-020-00090-5
dc.identifier.issn16742818
dc.identifier.urihttps://hdl.handle.net/1843/63162
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofInternational journal of oral science
dc.rightsAcesso Aberto
dc.subjectStem cells
dc.subjectOral submucous fibrosis
dc.subjectCarcinoma, squamous cell
dc.subjectNeoplasms
dc.subjectProteins
dc.subjectBiomarkers
dc.subjectMoloney murine leukemia virus
dc.subjectAldehyde dehydrogenase 1 family
dc.subjectDown-regulation
dc.subjectUp-regulation
dc.subject.otherLoss of oral mucosal stem cell markers in oral submucous fibrosis and their reactivation in malignant transformation fao clinica open acess assunto células tronco e Oral Submucous Fibrosis busca dia 26 do 10 2023
dc.titleLoss of oral mucosal stem cell markers in oral submucous fibrosis and their reactivation in malignant transformation
dc.typeArtigo de periódico
local.citation.epages
local.citation.issue1
local.citation.spage23
local.citation.volume12
local.description.resumoThe integrity of the basal stem cell layer is critical for epithelial homoeostasis. In this paper, we review the expression of oral mucosal stem cell markers (OM-SCMs) in oral submucous fibrosis (OSF), oral potentially malignant disorders (OPMDs) and oral squamous cell carcinoma (OSCC) to understand the role of basal cells in potentiating cancer stem cell behaviour in OSF. While the loss of basal cell clonogenicity triggers epithelial atrophy in OSF, the transition of the epithelium from atrophic to hyperplastic and eventually neoplastic involves the reactivation of basal stemness. The vacillating expression patterns of OM-SCMs confirm the role of keratins 5, 14, 19, CD44, β1-integrin, p63, sex-determining region Y box (SOX2), octamer-binding transcription factor 4 (Oct-4), c-MYC, B-cell-specific Moloney murine leukaemia virus integration site 1 (Bmi-1) and aldehyde dehydrogenase 1 (ALDH1) in OSF, OPMDs and OSCC. The downregulation of OM-SCMs in the atrophic epithelium of OSF and their upregulation during malignant transformation are illustrated with relevant literature in this review.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.nature.com/articles/s41368-020-00090-5

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