Two opposite extremes of adiposity similarly reduce inflammatory response of antigen-induced acute joint inflammation

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dc.creatorMarina Chaves de Oliveira
dc.creatorAna Letícia Malheiros Silveira
dc.creatorLuciana Pádua Tavares
dc.creatorDébora Fernandes Rodrigues
dc.creatorFons A. J. van de Loo
dc.creatorLirlândia Pires de Sousa
dc.creatorMauro Martins Teixeira
dc.creatorFlávio Almeida Amaral
dc.creatorAdaliene Versiani Matos Ferreira
dc.date.accessioned2022-03-21T21:01:06Z
dc.date.accessioned2025-09-09T00:54:02Z
dc.date.available2022-03-21T21:01:06Z
dc.date.issued2017
dc.identifier.doihttps://doi.org/10.1016/j.nut.2016.05.008
dc.identifier.issn0899-9007
dc.identifier.urihttps://hdl.handle.net/1843/40292
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofNutrition
dc.rightsAcesso Restrito
dc.subjectDieta
dc.subjectArtrite
dc.subjectMetabolismo
dc.subjectInflamação
dc.subjectAdipócitos
dc.subject.otherDiet
dc.subject.otherArthritis
dc.subject.otherMetabolism
dc.subject.otherInflammation
dc.subject.otherAdipocytes
dc.titleTwo opposite extremes of adiposity similarly reduce inflammatory response of antigen-induced acute joint inflammation
dc.typeArtigo de periódico
local.citation.epage140
local.citation.spage132
local.citation.volume33
local.description.resumoObjective: Acute inflammation is a normal response of tissue to an injury. During this process, inflammatory mediators are produced and metabolic alterations occur. Adipose tissue is metabolically activated, and upon food consumption, it disrupts the inflammatory response. However, little is known about the acute inflammatory response in joints that results from diet-induced adipose tissue remodeling. The objective of this study was to determine whether alterations in adipose tissue mass arising from food consumption modify the inflammatory response of antigen-induced joint inflammation in mice. Methods:Male BALB/c mice were fed a chow diet, a highly refined carbohydrate-containing (HC) diet for 8 wk. They were then immunized and, after 2 wk, received a knee injection of methylated bovine serum albumin (mBSA). They were sacrificed at 6, 24, and 48 h after injection. The effect of the cafeteria diet for 8 wk, which also increases adipose tissue, or conjugated linoleic acid (CLA) supplementation for 4 wk, a model of lipodystrophy, was evaluated 24 h after knee challenge with mBSA. Results: Cellular influx, predominantly neutrophils, in synovial fluid was attenuated in the HC diet group, as were levels of myeloperoxidase and IL-1β in periarticular tissue and histopathological analysis. These responses were associated with reduced adiponectin and increased leptin in serum, which was pronounced in mice fed the HC diet. Cafeteria diet and CLA supplementation induced a profile similar to that seen with the HC diet in terms of inflammation, disease response, and metabolic alteration. Interestingly, after the injection of mBSA, the area of adipocytes in the infrapatellar fat pad increased in mice fed with chow diet similar to those fed the HC and cafeteria diet. Conclusions: We demonstrated that attenuation of joint response induced by diet was independent of adipose tissue remodeling but could be associated with metabolic alterations.
local.publisher.countryBrasil
local.publisher.departmentENF - DEPARTAMENTO DE NUTRIÇÃO
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0899900716300818

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