Omega-3 fatty acid supplementation attenuates intestinal mucositis and tumor growth in a murine model of breast cancer.

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dc.creatorAline Luiza Afonso de Souza
dc.creatorTatiani Uceli Maioli
dc.creatorValbert Nascimento Cardoso
dc.creatorDanyelle M. Townsend
dc.creatorAndré Luis Branco de Barros
dc.creatorSimone de Vasconcelos Generoso
dc.creatorLuísa Martins Trindade
dc.creatorAmanda Dias Borges
dc.creatorPaola Caroline Lacerda Leocadio
dc.creatorJuliana de Oliveira Silva
dc.creatorRenata Salgado Fernandes
dc.creatorJaqueline Isaura Alvarez Leite
dc.creatorGeovanni Dantas Cassali
dc.creatorDiego Carlos dos Reis
dc.date.accessioned2025-08-28T18:03:15Z
dc.date.accessioned2025-09-09T00:58:55Z
dc.date.available2025-08-28T18:03:15Z
dc.date.issued2024-04
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.jff.2024.106096
dc.identifier.issn1756-4646
dc.identifier.urihttps://hdl.handle.net/1843/84688
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Functional Foods
dc.rightsAcesso Aberto
dc.subjectÁcidos Graxos Ômega-3
dc.subjectÁcido Eicosapentaenoico
dc.subjectDi-Hidroxiacetona
dc.subjectMucosite
dc.subject.otherOmega-3
dc.subject.otherEPA
dc.subject.otherDHA
dc.subject.other4T1 cells
dc.subject.otherIntestinal mucositis
dc.titleOmega-3 fatty acid supplementation attenuates intestinal mucositis and tumor growth in a murine model of breast cancer.
dc.typeArtigo de periódico
local.citation.epage10
local.citation.spage1
local.citation.volume115
local.description.resumoThe potential use of Omega-3 fatty acid for its anti-inflammatory properties has been proposed to alleviate the side effects of cancer therapeutics. Fifty female BALB/c mice were randomly assigned to five treatment groups. Mice were injected with Murine 4 T1 breast cancer cells, and 5-fluorouracil (5-FU) to induce mucositis. The mice were provided control or chow supplemented with Omega-3 fatty acid (fish oil with 15 % EPA and 7 % DHA, respectively). Our results showed that, the use of Omega-3 prevented intestinal mucositis by reducing intestinal permeability and restoring histological parameters. Additionally, Omega-3 supplementation enhanced the antineoplastic effect of 5-FU, as evidenced by a greater reduction in tumor growth compared to the other groups. Furthermore, the combined administration of 5-FU and Omega-3 significantly reduced the formation of lung metastasis. Collectively, these findings suggest that Omega-3 supplementation, particularly in conjunction with 5-FU, may contribute to the treatment of cancer by decreasing induced intestinal mucositis
local.publisher.countryBrasil
local.publisher.departmentENF - DEPARTAMENTO DE NUTRIÇÃO
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S1756464624000987

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