Different combinations of the GLIM criteria for patients awaiting a liver transplant: poor performance for malnutrition diagnosis but a potentially useful prognostic tool

Página do item simplificado
dc.creatorBárbara Chaves Santos
dc.creatorAna Luisa Ferreira Fonseca
dc.creatorLívia Garcia Ferreira
dc.creatorHelem Sena Ribeiro
dc.creatorMaria Isabel Toulson Davisson Correia
dc.creatorAgnaldo Soares Lima
dc.creatorFrancisco Guilherme Cancela e Penna
dc.creatorLucilene Rezende Anastácio
dc.date.accessioned2025-01-24T18:45:09Z
dc.date.accessioned2025-09-08T23:00:44Z
dc.date.available2025-01-24T18:45:09Z
dc.date.issued2022-01
dc.identifier.doihttps://doi.org/10.1016/j.clnu.2021.11.008
dc.identifier.issn02615614
dc.identifier.urihttps://hdl.handle.net/1843/79476
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofClinical Nutrition
dc.rightsAcesso Restrito
dc.subjectPacientes
dc.subjectTransplante
dc.subjectFígado
dc.subjectDesnutrição
dc.subject.otherCirrose
dc.subject.otherTransplante de fígado
dc.subject.otherDesnutrição
dc.subject.otherMortalidade
dc.titleDifferent combinations of the GLIM criteria for patients awaiting a liver transplant: poor performance for malnutrition diagnosis but a potentially useful prognostic tool
dc.typeArtigo de periódico
local.citation.epage104
local.citation.issue1
local.citation.spage97
local.citation.volume41
local.description.resumoBackground & aims Studies using the Global Leadership Initiative on Malnutrition (GLIM) criteria for patients with liver cirrhosis are limited. This study aimed to assess the impact of malnutrition according to the GLIM criteria on the outcomes of patients awaiting a liver transplant (LTx) and compare these criteria with Subjective Global Assessment (SGA). Methods This retrospective observational study included adult patients awaiting LTx. Patient clinical data, nutritional status according to various tools including SGA, and resting energy expenditure were assessed. The distinct phenotypic and etiologic criteria provided 36 different GLIM combinations. The GLIM criteria and SGA were compared using the kappa coefficient. The variables associated with mortality before and after the LTx and with a longer length of stay (LOS) after LTx (≥18 days) were assessed by Cox regression and logistic regression analyses, respectively. Results A total of 152 patients were included [median age 52.0 (interquartile range: 46.5–59.5) years; 66.4% men; 63.2% malnourished according to SGA]. The prevalence of malnutrition according to the GLIM criteria ranged from 0.7% to 30.9%. The majority of the GLIM combinations exhibited poor agreement with SGA. Independent predictors of mortality before and after LTx were presence of ascites or edema (p = 0.011; HR:2.58; CI95%:1.24–5.36), GLIM 32 (PA-phase angle + MELD) (p = 0.026; HR:2.08; CI95%:1.09–3.97), GLIM 33 (PA + MELD-Na ≥ 12) (p = 0.018; HR:2.17; CI95%:1.14–4.13), and GLIM 34 (PA + Child–Pugh) (p = 0.043; HR:1.96; CI95%:1.02–3.77). Malnutrition according to GLIM 28 (handgrip strength + Child-Pugh) was independently associated with a longer LOS (p = 0.029; OR:7.21; CI95%:1.22–42.50). Conclusion The majority of GLIM combinations had poor agreement with SGA, and 4 of the 36 GLIM combinations were independently associated with adverse outcomes.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.departmentMED - DEPARTAMENTO DE CIRURGIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/abs/pii/S0261561421005094

Arquivos

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG