Effect of letrozole in carcinogen-plus-estrogen-induced endometrial hyperplasia in mice

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dc.creatorAlessandra Cerávololara
dc.creatorEduardo Batista Cândido
dc.creatorPaula Vieira Vidigal
dc.creatorAna Luiza Lunardi Rocha
dc.creatorAlessandra Costa Carvalho-macedo
dc.creatorMarcia Mendonca Carneiro
dc.creatorAgnaldo Lopes Silva-filho
dc.date.accessioned2023-07-11T20:46:39Z
dc.date.accessioned2025-09-09T00:25:21Z
dc.date.available2023-07-11T20:46:39Z
dc.date.issued2016
dc.format.mimetypepdf
dc.identifier.doi10.1590/S0102-865020160040000010
dc.identifier.issn16782674
dc.identifier.urihttps://hdl.handle.net/1843/56084
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofActa Cirúrgica Brasileira
dc.rightsAcesso Aberto
dc.subjectHiperplasia Endometrial
dc.subjectEstrogênio
dc.subjectNeoplasias do Endométrio
dc.subjectLetrozol
dc.subject.otherEndometrial hyperplasia
dc.subject.otherEndometrial cancer
dc.subject.otherEstrogen
dc.subject.otherLetrozole
dc.titleEffect of letrozole in carcinogen-plus-estrogen-induced endometrial hyperplasia in mice
dc.typeArtigo de periódico
local.citation.epage293
local.citation.issue4
local.citation.spage286
local.citation.volume31
local.description.resumoPURPOSE: To evaluate the effects of letrozole (Ltz) in carcinogen+estrogen-induced endometrial hyperplasia. METHODS: BALB/c female mice were divided into four groups of 12 animals each receiving an intrauterine dose of N-ethyl-Nnitrosourea (ENU) and weekly subcutaneous injections of estradiol hexaidrobenzoate (EHB), except for group I(control). The groups were divided in I (control), II (ENU+EHB), III (ENU+EHB+MPA) and IV (ENU+EHB+Ltz). Group III also received intramuscular injections of MPA (medroxy progesterone acetate) every four weeks, while group IV received oral doses of Ltz daily. At the end of 16 weeks, the animals were sacrificed, and blood samples were collected for the measurement of serum estradiol and progesterone levels. Uterine histological sections were made to evaluate the presence of endometrial proliferative lesions. Differences between groups were evaluated with student’s t test, ANOVA and chi-square test.RESULTS: Groups ENU+EHB, ENU+EHB+MPA and ENU+EHB+Ltz showed varying degrees of endometrial hyperplasia. The incidence of hyperplasia in groups ENU+EHB and ENU+EHB+Ltz was higher and more severe than in group ENU+EHB+MPA. Control group showed lower levels of serum estradiol than the other groups. CONCLUSION: There was no evidence that letrozole could act as an antiestrogenic drug in the development of endometrial proliferative lesions.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE ANATOMIA PATOLÓGICA E MEDICINA LEGAL
local.publisher.departmentMED - DEPARTAMENTO DE GINECOLOGIA OBSTETRÍCIA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/acb/a/5Nxqg4tcxSRqhRFSK6HqJMB/?lang=en

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