DNA methylation patterns of genes related to immune response in the different clinical forms of oral lichen planus

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dc.creatorAline Fernanda Cruz
dc.creatorRenata Gonçalves de Resende
dc.creatorJúlio César Tanos de Lacerda
dc.creatorNubia Braga Pereira
dc.creatorLeonardo Augusto de Melo
dc.creatorMarina Gonçalves Diniz
dc.creatorCarolina Cavalieri Gomes
dc.creatorRicardo Santiago Gomez
dc.date.accessioned2025-07-03T19:05:17Z
dc.date.accessioned2025-09-09T00:19:06Z
dc.date.available2025-07-03T19:05:17Z
dc.date.issued2018-01
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1111/jop.12645
dc.identifier.issn1600-0714
dc.identifier.urihttps://hdl.handle.net/1843/83317
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Oral Pathology & Medicine
dc.rightsAcesso Restrito
dc.subjectEpigenomics
dc.subjectInflammation
dc.subjectLichen planus
dc.subjectMethylation
dc.subjectLichen planus, oral
dc.subjectGenes
dc.subjectDental plaque
dc.subjectTooth erosion
dc.subjectImmunity
dc.subject.otherEpigenetic
dc.subject.otherInflammation
dc.subject.otherLichen planus
dc.subject.otherMethylation
dc.subject.otherOral lichen planus
dc.titleDNA methylation patterns of genes related to immune response in the different clinical forms of oral lichen planus
dc.typeArtigo de periódico
local.citation.epage95
local.citation.issue1
local.citation.spage91
local.citation.volume47
local.description.resumoBackground: The oral lichen planus is a chronic inflammatory disease. Although its aetiology is not well understood, the role of T lymphocytes in its inflammatory events is recognised. Identifying the epigenetic mechanisms involved in the pathogenesis of this immune-mediated condition is fundamental for understanding the inflammatory reaction that occurs in the disease. The purpose of this work was to evaluate the methylation pattern of 21 immune response-related genes in the different clinical forms of oral lichen planus. Methods: A cross-sectional study was performed to analyse the DNA methylation patterns in three distinct groups of oral lichen planus: (i) reticular/plaque lesions; (ii) erosive lesions; (iii) normal oral mucosa (control group). After DNA extraction from biopsies, the samples were submitted to digestions by methylation-sensitive and methylation-dependent enzymes and double digestion. The relative percentage of methylated DNA for each gene was provided using real-time polymerase chain reaction arrays. Results: Hypermethylation of the STAT5A gene was observed only in the control group (59.0%). A higher hypermethylation of the ELANE gene was found in reticular/plaque lesions (72.1%) compared to the erosive lesions (50.0%). Conclusion: Our results show variations in the methylation profile of immune response-related genes, according to the clinical type of oral lichen planus after comparing with the normal oral mucosa. Further studies are necessary to validate these findings using gene expression analysis.
local.identifier.orcidhttps://orcid.org/0000-0002-5570-3550
local.identifier.orcidhttps://orcid.org/0000-0002-6714-3124
local.identifier.orcidhttps://orcid.org/0000-0003-3081-7778
local.identifier.orcidhttps://orcid.org/0000-0002-4212-1172
local.identifier.orcidhttps://orcid.org/0000-0003-1580-4995
local.identifier.orcidhttps://orcid.org/0000-0001-8770-8009
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.12645

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