Inhibiting constitutive neurogenesis compromises long-term social recognition memory

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dc.creatorAna Raquel Pereira-Caixeta
dc.creatorLeonardo de Oliveira Guarnieri
dc.creatorDaniel Castro Medeiros
dc.creatorEduardo Mazoni Andrade Marçal Mendes
dc.creatorLuiz Carlos Duarte Ladeira
dc.creatorMárcio Tadeu Pereira
dc.creatorMarcio Flavio Dutra Moraes
dc.creatorGrace Schenatto Pereira Moraes
dc.date.accessioned2025-04-24T19:00:11Z
dc.date.accessioned2025-09-09T00:20:21Z
dc.date.available2025-04-24T19:00:11Z
dc.date.issued2018
dc.identifier.doihttps://doi.org/10.1016/j.nlm.2018.06.014
dc.identifier.issn1074-7427
dc.identifier.urihttps://hdl.handle.net/1843/81830
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofNeurobiology of learning and memory
dc.rightsAcesso Aberto
dc.subjectNeurologia do desenvolvimento
dc.subject.otherSocial recognition memory
dc.subject.otherNeurogenesis
dc.subject.otherHippocampus
dc.subject.otherOlfactory bulb
dc.titleInhibiting constitutive neurogenesis compromises long-term social recognition memory
dc.typeArtigo de periódico
local.citation.epage103
local.citation.spage92
local.citation.volume155
local.description.resumoAlthough the functional role for newborn neurons in neural circuits is still matter of investigation, there is no doubt that neurogenesis modulates learning and memory in rodents. In general, boosting neurogenesis before learning, using genetic-target tools or drugs, improves hippocampus-dependent memories. However, inhibiting neurogenesis may yield contradictory results depending on the type of memory evaluated. Here we tested the hypothesis that inhibiting constitutive neurogenesis would compromise social recognition memory (SRM). Male Swiss mice were submitted to three distinct procedures to inhibit neurogenesis: (1) intra-cerebral infusion of Cystosine-β-D-Arabinofuranoside (AraC); (2) intra-peritoneal injection of temozolomide (TMZ) and (3) cranial gamma irradiation. All three methods decreased cell proliferation and neurogenesis in the dentate gyrus of the dorsal (dDG) and ventral hippocampus (vDG), and the olfactory bulb (OB). However, the percentage inhibition diverged between methods and brain regions. Ara-C, TMZ and gamma irradiation impaired SRM, though only gamma irradiation did not cause side effects on weight gain, locomotor activity and anxiety. Finally, we examined the contribution of cell proliferation in vDG, dDG and OB to SRM. The percent of inhibition in the dDG correlates with SRM, independently of the method utilized. This correlation was observed for granular cell layer of OB and vDG, only when the inhibition was induced by gamma irradiation. Animal's performance was restrained by the inhibition of dDG cell proliferation, suggesting that cell proliferation in the dDG has a greater contribution to SRM. Altogether, our results demonstrate that SRM, similarly to other hippocampus-dependent memories, has its formation impaired by reducing constitutive neurogenesis.
local.publisher.countryBrasil
local.publisher.departmentENG - DEPARTAMENTO DE ENGENHARIA ELETRÔNICA
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S1074742718301527?via%3Dihub

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