Use of biomarkers for predicting a malignant course in acute ischemic stroke: an observational case-control study

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dc.creatorAlexandre Guimarães de Almeida Barros
dc.creatorLucas Roquim e Silva
dc.creatorAlberlúcio Pessoa
dc.creatorAntonio Eiras Falcão
dc.creatorLuiz Alexandre Viana Magno
dc.creatorDaniela Valadão Freitas Rosa
dc.creatorMarco Aurelio Romano Silva
dc.creatorDebora Marques de Miranda
dc.creatorRodrigo Nicolato
dc.date.accessioned2025-02-06T22:16:27Z
dc.date.accessioned2025-09-09T00:01:53Z
dc.date.available2025-02-06T22:16:27Z
dc.date.issued2023-09-26
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1038/s41598-023-43408-z
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/1843/79742
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofScientific Reports
dc.rightsAcesso Aberto
dc.subjectCérebro
dc.subjectAcidente vascular cerebral
dc.subjectIsquemia cerebral
dc.subjectMarcadores bioquímicos
dc.titleUse of biomarkers for predicting a malignant course in acute ischemic stroke: an observational case-control study
dc.typeArtigo de periódico
local.citation.epage09
local.citation.spage01
local.citation.volume13
local.description.resumoAcute ischemic stroke is a sudden neurological event caused by brain ischemia. Patients with large vessel occlusion are at high risk of developing signifcant cerebral edema, which can lead to rapid neurological decline. The optimal timing for decompressive hemicraniectomy to prevent further brain damage is still uncertain. This study aimed to identify potential predictors of severe brain edema. The data indicate that specifc cytokines may help identify patients with a higher risk of developing life-threatening brain swelling in the early phase post-stroke. The association between a positive biomarker and the outcome was calculated, and three biomarkers—S100B protein, MMP-9, and IL-10—were found to be signifcantly associated with malignant edema. A model was derived for early predicting malignant cerebral edema, including S100B protein and IL-1 beta. These fndings suggest that molecular biomarkers related to the ischemic cascade may be a helpful way of predicting the development of malignant cerebral edema in ischemic stroke patients, potentially widening the time window for intervention and assisting in decision-making. In conclusion, this study provides insights into the molecular mechanisms of severe brain edema and highlights the potential use of biomarkers in predicting the course of ischemic stroke.
local.identifier.orcidhttps://orcid.org/0000-0002-8042-4844
local.identifier.orcidhttps://orcid.org/0000-0002-8150-9022
local.identifier.orcidhttps://orcid.org/0000-0003-3693-1897
local.identifier.orcidhttps://orcid.org/0000-0003-4959-9459
local.identifier.orcidhttps://orcid.org/0000-0002-6558-4639
local.identifier.orcidhttps://orcid.org/0000-0003-1585-7720
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentMED - DEPARTAMENTO DE PSIQUIATRIA E NEUROLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTAL
local.publisher.initialsUFMG
local.url.externahttps://www.nature.com/articles/s41598-023-43408-z

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