BDNF/trkb/akt signaling pathway epithelial odontogenic tumors and keratocyst: an immunohistochemical study comparative with dental germs

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dc.creatorVinicius Coelho Carrard
dc.creatorFelipe Paiva Fonseca
dc.creatorManoela Domingues Martins
dc.creatorFlorencia Dornelles
dc.creatorVivian Wagner
dc.creatorCarla Ariotti
dc.creatorVinicius Carrard
dc.creatorPablo Vargas
dc.creatorCeleste Sánchez-Romero
dc.creatorVeronica Beovide
dc.date.accessioned2024-02-19T18:21:38Z
dc.date.accessioned2025-09-09T00:49:51Z
dc.date.available2024-02-19T18:21:38Z
dc.date.issued2021
dc.identifier.doi10.1097/pai.0000000000000874
dc.identifier.issn15412016
dc.identifier.urihttps://hdl.handle.net/1843/64246
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofApplied immunohistochemistry & molecular morphology
dc.rightsAcesso Restrito
dc.subjectAmeloblastoma
dc.subjectSignal transduction
dc.subjectBrain-derived neurotrophic factor
dc.subjectReceptor, trkB
dc.subjectProteins
dc.subjectPhosphorylation
dc.subjectRibosomal protein S6
dc.subjectImmunohistochemistry
dc.subjectNeoplasms
dc.subjectOdontogenic cysts
dc.subject.otherTumores odontogênicos 5 depósitos de trabalhos de pós-graduação próximo depósito 01data de busca de publicação 21/12/2023 cheguei na hora 15h e 18min do dia 15 do 12 dezembro de 2023acesso restrito assunto Ameloblastoma fao clínica busca dia 01/12/2023 Bdnf/trkb/akt signaling pathway epithelial odontogenic tumors and keratocyst: an immunohistochemical study comparative with dental germs
dc.subject.othercistos odontogênicos Key Words: odontogenic lesions, growth factor, signaling path way, mTOR, BDNF, TrkB
dc.subject.othertítulo periódico Applied immunohistochemistry & molecular morphology
dc.subject.other5 depósitos de trabalhos de pós-graduação próximo depósito 01data de busca de publicação 21/12/2023 cheguei na hora 15h e 18min do dia 15 do 12 dezembro de 2023acesso restrito assunto Ameloblastoma fao clínica busca dia 01/12/2023 Bdnf/trkb/akt signaling pathway epithelial odontogenic tumors and keratocyst: an immunohistochemical study comparative with dental germs
dc.titleBDNF/trkb/akt signaling pathway epithelial odontogenic tumors and keratocyst: an immunohistochemical study comparative with dental germs
dc.typeArtigo de periódico
local.citation.epage373
local.citation.issue5
local.citation.spage366
local.citation.volume29
local.description.resumoOdontogenic lesions (OL) are an important group of oral and maxillofacial diseases represented by odontogenic cysts, benign, and malignant tumors. The brain-derived neurotrophic factor (BDNF)/ tropomyosin receptor kinase B (TrkB) signaling pathway has multiple biological actions and has been identified as an important pathway in the proliferation, invasion, and survival of different epithelial tumors. Its role in the development of OL, however, has so far been unexplored. Our aim was to evaluate the BDNF/TrkB/Akt/p-RPS6 signaling pathway in OL of epithelial origin. This cross-sectional study comprised 3 cases of tooth germs, 25 cases of odontogenic keratocyst (OK), 29 cases of ameloblastoma (Am), and 6 cases of ameloblastic carcinoma. Immunohistochemical staining for BDNF, TrkB, p-Akt, and p-RPS6 was performed. OLs were evaluated according to the pattern of immunohistochemical expression in epithelial cells and by semiquantitative scores that considered the intensity of staining and percentage of positive cells. BDNF stromal expression was also assessed. No significant differences were observed with respect to the percentage of positive cases for all markers. Regarding the immunoreactive scores, BDNF and p-RPS6 expressions were similar in the odontogenic epithelium of all OL. However, TrkB and p-Akt were overexpressed in OK compared with ameloblastic carcinoma. In Am, epithelial BDNF was significantly higher compared with stromal expression. In conclusion, BDNF seems to participate in the development of cystic, benign, and malignant odontogenic epithelium to similar degrees. The acquisition of the invasive or malignant phenotype in odontogenic neoplasms is not associated with alterations in the BDNF/TrkB/Akt/RPS6 axis, which could be implicated in the differentiation process.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://journals.lww.com/appliedimmunohist/fulltext/2021/05000/bdnf_trkb_akt_signaling_pathway_epithelial.6.aspx

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