Lactobacillus delbrueckii CIDCA 133 Ameliorates Chemotherapy-Induced Mucositis by Modulating Epithelial Barrier and TLR2/4/Myd88/NF-κB Signaling Pathway

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dc.creatorFernanda Alvarenga Lima Barroso
dc.creatorEnio Ferreira
dc.creatorFlaviano Dos Santos Martins
dc.creatorMariana Martins Drumond
dc.creatorPamela Mancha-agresti
dc.creatorAlexander Birbrair
dc.creatorDebmalya Barh
dc.creatorVasco Azevedo
dc.creatorLuís Cláudio Lima de Jesus
dc.creatorTales Fernando da Silva
dc.creatorViviane Lima Batista
dc.creatorJuliana Laguna
dc.creatorNina Dias Coelho-Rocha
dc.creatorKátia Duarte Vital
dc.creatorSimone Odília Antunes Fernandes
dc.creatorValbert Nascimento Cardoso
dc.date.accessioned2023-11-06T20:29:56Z
dc.date.accessioned2025-09-08T23:52:15Z
dc.date.available2023-11-06T20:29:56Z
dc.date.issued2022
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3389/fmicb.2022.858036
dc.identifier.issn1664-302X
dc.identifier.urihttps://hdl.handle.net/1843/60508
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofFrontiers in Microbiology
dc.rightsAcesso Aberto
dc.subjectMucosite
dc.subjectTumores
dc.subjectProbióticos
dc.subjectTratamento Farmacológico
dc.subject.otherMucosite
dc.subject.otherTumores
dc.subject.otherProbióticos
dc.subject.otherTratamento Farmacológico
dc.titleLactobacillus delbrueckii CIDCA 133 Ameliorates Chemotherapy-Induced Mucositis by Modulating Epithelial Barrier and TLR2/4/Myd88/NF-κB Signaling Pathway
dc.typeArtigo de periódico
local.citation.spage858036
local.citation.volume13
local.description.resumoIntestinal mucositis promoted by the use of anticancer drugs is characterized by ulcerative inflammation of the intestinal mucosa, a debilitating side effect in cancer patients undergoing treatment. Probiotics are a potential therapeutic option to alleviate intestinal mucositis due to their effects on epithelial barrier integrity and anti-inflammatory modulation. This study investigated the health-promoting impact of Lactobacillus delbrueckii CIDCA 133 in modulating inflammatory and epithelial barrier markers to protect the intestinal mucosa from 5-fluorouracil-induced epithelial damage. L. delbrueckii CIDCA 133 consumption ameliorated small intestine shortening, inflammatory cell infiltration, intestinal permeability, villus atrophy, and goblet cell count, improving the intestinal mucosa architecture and its function in treated mice. Upregulation of Muc2, Cldn1, Hp, F11r, and Il10, and downregulation of markers involved in NF-κB signaling pathway activation (Tlr2, Tlr4, Nfkb1, Il6, and Il1b) were observed at the mRNA level. This work suggests a beneficial role of L. delbrueckii strain CIDCA 133 on intestinal damage induced by 5-FU chemotherapy through modulation of inflammatory pathways and improvement of epithelial barrier function.
local.identifier.orcidhttps://orcid.org/0000-0002-1835-0303
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentFARMACIA - FACULDADE DE FARMACIA
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.frontiersin.org/articles/10.3389/fmicb.2022.858036/full

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