Effect of probiotics on the maintenance of intestinal homeostasis after chemotherapy: systematic review and meta-analysis of pre-clinical studies

Página do item simplificado
dc.creatorWilliam Gustavo de Lima
dc.creatorRafaela Miranda Pessoa
dc.creatorKatia Duarte Vital
dc.creatorIsabella Kuniko Tavares Magalhaes Takenaka
dc.creatorValbert Nascimento Cardoso
dc.creatorSimone Odília Antunes Fernandes
dc.date.accessioned2022-05-19T23:24:32Z
dc.date.accessioned2025-09-08T23:09:23Z
dc.date.available2022-05-19T23:24:32Z
dc.date.issued2020
dc.identifier.doi10.3920/bm2019.0142
dc.identifier.issn1876-2883
dc.identifier.urihttps://hdl.handle.net/1843/41840
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBeneficial Microbes
dc.rightsAcesso Restrito
dc.subjectBifidobacterium
dc.subjectLactobacilos
dc.subjectMucosite gastrointestinal
dc.subject.otherBifidobacterium spp.
dc.subject.otherLactobacillus spp.
dc.subject.otherSaccharomyces spp.
dc.subject.otherGastrointestinal mucositis
dc.subject.otherIntestinal microbiota
dc.titleEffect of probiotics on the maintenance of intestinal homeostasis after chemotherapy: systematic review and meta-analysis of pre-clinical studies
dc.typeArtigo de periódico
local.citation.epage318
local.citation.issue4
local.citation.spage305
local.citation.volume11
local.description.resumoGastrointestinal mucositis (GIM) is an inflammation caused by antitumor therapy, especially after chemotherapy and radiotherapy. Currently in the clinical practice, only palliative measures are taken to treat GIM, representing the main clinical limitation in the management of this condition. Several studies have highlighted the potential benefits of probiotics for the management of GIM, but the actual role of these microorganisms in the maintenance of intestinal homeostasis remains elusive. In this context, here we aimed to realise a systematic review with meta-analysis to evaluate the effect of probiotics on experimental GIM. The meta-analysis showed that probiotics significantly suppressed the body weight loss related to GIM in rodents (95% confidence interval (CI): -2.67 to -0.70; I2=98%, P<0.00). Subgroup analysis showed that pre-treatment (≥7 days before chemotherapy) (95% CI: -8.84 to -0.17; I2=98%, P<0.04) with a high dose of probiotics (≥ 109 cfu/day) (95% CI: -2.58 to -0.28; I2=98%, P<0.00) comprising two or more microorganism species (95% CI: -6.49 to -0.28; I2=96%, P=0.03) remedied GIM more effectively. It was also revealed that fungi (specifically Saccharomyces boullardii) are more effective in remedying GIM than bacteria (P=0.03 vs P<0.00), and the mouse models are more receptive than rats to the enteroprotective effects of probiotics (95% CI: -4.76, -0.69; I2=97%, P=0.01). Qualitative analyses highlighted that probiotics suppress GIM through several mechanisms; they reduce the intestinal permeability, suppress the pro-inflammatory cytokine production while stimulating production and secretion of anti-inflammatory cytokines, inhibit the signalling pathways coupled to inflammation and apoptosis, accelerate the proliferation of enterocytes, reduce the levels of reactive oxygen species, and help maintain the protective mucus layer. In conclusion, this review highlights the therapeutic benefits of probiotics in experimental GIM.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.initialsUFMG
local.url.externahttps://www.wageningenacademic.com/doi/10.3920/BM2019.0142

Arquivos

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG