Gdf-15 levels in patients with polycystic ovary syndrome treated with metformin: a combined clinical and in silico pathway analysis

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dc.creatorFernanda Medeiros Vale Magalhaes
dc.creatorRodrigo Mendonça Cardoso Pestana
dc.creatorCláudia Natália Ferreira
dc.creatorIeda de Fatima Oliveira Silva
dc.creatorAna Lúcia Cândido
dc.creatorFlávia Ribeiro Oliveira
dc.creatorFernando Marcos dos Reis
dc.creatorKarina Braga Gomes
dc.date.accessioned2025-07-03T19:43:44Z
dc.date.accessioned2025-09-09T01:23:04Z
dc.date.available2025-07-03T19:43:44Z
dc.date.issued2024
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.20945/2359-4292-2023-0416
dc.identifier.issn2359-3997
dc.identifier.urihttps://hdl.handle.net/1843/83319
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofArchives of endocrinology and metabolism
dc.rightsAcesso Aberto
dc.subjectGrowth Differentiation Factor 15
dc.subjectPolycystic Ovary Syndrome
dc.subjectMetformin
dc.subject.otherGrowth Differentiation Factor 15
dc.subject.otherPolycystic Ovary Syndrome
dc.subject.otherMetformin
dc.subject.otherBiologic pathways
dc.titleGdf-15 levels in patients with polycystic ovary syndrome treated with metformin: a combined clinical and in silico pathway analysis
dc.typeArtigo de periódico
local.citation.epage9
local.citation.spage1
local.citation.volume68
local.description.resumoPolycystic ovary syndrome (PCOS) is an endocrine disease characterized by metabolic, reproductive, and psychological manifestations. Growth and differentiation factor 15 (GDF-15) is a cytokine associated with metabolic and inflammatory disorders. Metformin is commonly used for the treatment of PCOS. We investigated the relationship between GDF-15 levels and PCOS, the effect of metformin on GDF-15 levels, and potential biologic pathways related to GDF-15. Subjects and methods: The study included 35 women with PCOS and 32 women without PCOS (controls). Both groups were compared in terms of GDF-15 levels. Additional analysis was conducted on samples from 22 women with PCOS who were treated with either metformin (n = 7) or placebo (n = 15), retrieved from a previous randomized, controlled trial. Levels of GDF-15 were measured using MILLIPLEX. The biologic pathways related to GDF-15 were evaluated using the databases STRING, SIGNOR, and Pathway Commons. The statistical analysis was conducted using the software SPSS. Results: Levels of GDF-15 were higher in the PCOS group compared with the non-PCOS group (p = 0.039). Among women with PCOS, GDF-15 levels were higher in those treated with metformin compared with placebo (p = 0.007). The proteins related to GDF-15 overlapped between the databases, and a significant interaction was found between GDF-15 and proteins related to PCOS and its complications, including those related to estrogen response, oxidative stress, ovarian infertility, interleukin (IL)-18, IL-4, the ratio of advanced glycation end products to their receptor (AGE/RAGE), leptin, transforming growth factor beta (TGF-β), adipogenesis, and insulin. Conclusion: The findings of the present study suggest a relationship between GDF-15 and PCOS and a potential increase in GDF-15 levels with metformin treatment. An additional finding was that GDF-15 could be involved in biologic pathways related to PCOS complications.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentMED - DEPARTAMENTO DE GINECOLOGIA OBSTETRÍCIA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/aem/a/GtcSgg8MZBnGgdmFM9TMfns/?format=pdf&lang=en

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