Supramolecular magnetonanohybrids for multimodal targeted therapy of triple-negative breast cancer cells

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dc.creatorAlexandra Ancelmo Piscitelli Mansur
dc.creatorHerman Sander Mansur
dc.creatorAlice Gameiro Leonel
dc.creatorIsadora Cota Carvalho
dc.creatorManuela C. G. Lage
dc.creatorSandhra Maria de Carvalho
dc.creatorKlaus Wilhelm Heinrich Krambrock
dc.creatorZélia Inês Portela Lobato
dc.date.accessioned2022-11-10T19:17:56Z
dc.date.accessioned2025-09-09T01:23:07Z
dc.date.available2022-11-10T19:17:56Z
dc.date.issued2020
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipFINEP - Financiadora de Estudos e Projetos, Financiadora de Estudos e Projetos
dc.identifier.doihttps://doi.org/10.1039/d0tb01175d
dc.identifier.issn2050750X
dc.identifier.urihttps://hdl.handle.net/1843/47143
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Materials Chemistry B
dc.rightsAcesso Restrito
dc.subjectCâncer
dc.subject.otherCancer
dc.subject.otherMultimodal targeted therapy
dc.titleSupramolecular magnetonanohybrids for multimodal targeted therapy of triple-negative breast cancer cells
dc.typeArtigo de periódico
local.citation.epage7188
local.citation.issue32
local.citation.spage7166
local.citation.volume8
local.description.resumoDespite the undeniable advances in recent decades, cancer remains one of the deadliest diseases of the current millennium, where the triple-negative breast cancer (TNBC) is very aggressive, extremely metastatic, and resistant to conventional chemotherapy. The nanotheranostic approach focusing on targeting membrane receptors often expressed at abnormal levels by cancer cells can be a strategic weapon for fighting malignant tumors. Herein, we introduced a novel “all-in-one nanosoldier” made of colloidal hybrid nanostructures, which were designed for simultaneously targeting, imaging, and killing TNBC cells. These nanohybrids comprised four distinct components: (a) superparamagnetic iron oxide nanoparticles, as bi-functional nanomaterials for inducing ferroptosis via inorganic nanozyme-mediated catalysis and magnetotherapy by hyperthermia treatment; (b) carboxymethyl cellulose biopolymer, as a water-soluble capping macromolecule; (c) folic acid, as the membranotopic vector for targeting folate receptors; (d) and doxorubicin (DOX) drug for chemotherapy. The results demonstrated that this novel strategy was highly effective for targeting and killing TNBC cells in vitro, expressing high levels of folate membrane-receptors. The results evidenced that three integrated mechanisms triggered the deaths of the cancer cells in vitro: (a) ferroptosis, by magnetite nanoparticles inducing a Fenton-like reaction; (b) magneto-hyperthermia effect by generating heat under an alternate magnetic field; and (c) chemotherapy, through the DOX intracellular release causing DNA dysfunction. This “all-in-one nanosoldier” strategy offers a vast realm of prospective alternatives for attacking cancer cells, combining multimodal therapy and the delivery of therapeutic agents to diseased sites and preserving healthy cells, which is one of the most critical clinical challenges faced in fighting drug-resistant breast cancers.
local.identifier.orcidhttps://orcid.org/0000-0003-1526-2508
local.identifier.orcidhttps://orcid.org/0000-0002-3032-495X
local.identifier.orcidhttps://orcid.org/0000-0002-8798-4182
local.identifier.orcidhttps://orcid.org/0000-0003-2929-3452
local.identifier.orcidhttps://orcid.org/0000-0001-6665-8647
local.identifier.orcidhttps://orcid.org/0000-0002-7562-0285
local.identifier.orcidhttps://orcid.org/0000-0001-6665-8647
local.publisher.countryBrasil
local.publisher.departmentENG - DEPARTAMENTO DE ENGENHARIA METALÚRGICA
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.departmentVET - DEPARTAMENTO DE MEDICINA VETERINÁRIA PREVENTIVA
local.publisher.initialsUFMG
local.url.externahttps://pubs.rsc.org/en/content/articlelanding/2020/tb/d0tb01175d

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