Brazilian cerrado plant (arnica) Lychnophora ericoides Mart. (Asteraceae) toxicity characterization in mice

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dc.creatorBarbhara Mota Marinho
dc.creatorAndré Luiz Sena Guimarães
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorSérgio Henrique Sousa Santos
dc.creatorVictor Hugo Dantas Guimarães
dc.creatorJaciara Neves Sousa
dc.creatorDaniel Silva Moraes
dc.creatorEmisael Stênio Batista Gomes
dc.creatorClaudia Regina Vieira
dc.creatorSidnei Tavares dos Reis
dc.creatorTheles de Oliveira Costa
dc.creatorLucyana Conceição Farias
dc.date.accessioned2023-11-08T13:46:56Z
dc.date.accessioned2025-09-08T22:57:47Z
dc.date.available2023-11-08T13:46:56Z
dc.date.issued2022
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.phyplu.2021.100154
dc.identifier.issn2667-0313
dc.identifier.urihttps://hdl.handle.net/1843/60641
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPhytomedicine Plus
dc.rightsAcesso Aberto
dc.subjectArnica
dc.subjectToxicidade aguda
dc.subjectCerrados
dc.titleBrazilian cerrado plant (arnica) Lychnophora ericoides Mart. (Asteraceae) toxicity characterization in mice
dc.typeArtigo de periódico
local.citation.epage11
local.citation.spage1
local.citation.volume2
local.description.resumoBackground: Lychnophora ericoides Mart. (Asteraceae) is a Brazilian plant commonly used in folk medicine to treat pain and inflammation by topical administration. In recent years, this medicine has begun to be used orally. However, no study concerning its toxicity profile has been reported. Objective: The study evaluates the potential toxicity of the ethanolic extract from leaves of the Lychnophora ericoides, through the methods of acute and sub-acute oral administration in mice. Method: An acute toxicity study was performed according to the Organization for Economic Cooperation and Development protocol (OECD 423). A single extract dose of 50, 300, and 2000 mg/kg (n =3/group) was administered orally to female Swiss mice. For subacute toxicity, the protocol OECD 407 was followed. Doses of 50, 300, and 500 mg/kg (n =10/group) of the extract were administered daily to Swiss mice of both sexes for 28 days. Abnormal behavior, muscle strength, toxic symptoms, weight, and death were observed when assessing toxicity. Biochemical analysis, hematological analysis, macroscopic examination, and histopathological examination of several organs were conducted at the end of the treatment period. Results: In acute and subacute toxicity, the extract did not produce mortality. The acute toxicity study revealed alterations in the behavioral test and histopathological changes in the liver, kidney, lung, and spleen. The subacute oral toxicity test showed changes in hematologic and biochemical parameters. Histopathological examination of liver, kidney, spleen, lung, and heart indicated degenerative characteristics with inflammatory infiltrates focus. Conclusion: The study results suggest that oral use of Lychnophora ericoides leaves extract should be performed with caution in low doses in both single and repeated administrations.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S2667031321001366#

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