International clones of extended-spectrum β-lactamase (CTX-M)-producing Escherichia coli in peri-urban wild animals, Brazil

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dc.creatorMarcelo Pires Nogueira de Carvalho
dc.creatorMiriam R. Fernandes
dc.creatorFábio P. Sellera
dc.creatorRalf Lopes
dc.creatorDaniel F. Monte
dc.creatorAlícia G. Hippólito
dc.creatorLiliane Milanelo
dc.creatorTânia F. Raso
dc.creatorNilton Lincopan
dc.date.accessioned2024-05-28T14:55:22Z
dc.date.accessioned2025-09-09T00:27:04Z
dc.date.available2024-05-28T14:55:22Z
dc.date.issued2020
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.identifier.doihttps://doi.org/10.1111/tbed.13558
dc.identifier.issn1865-1682
dc.identifier.urihttps://hdl.handle.net/1843/68726
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofTransboundary and Emerging Diseases
dc.rightsAcesso Aberto
dc.subjectEscherichia coli
dc.subjectBactérias Gram-Negativas
dc.subjectAnimais selvagens
dc.subject.otherEnterobacterales
dc.subject.otherESBL
dc.subject.otherMDR bacteria
dc.subject.otherResistome
dc.subject.otherWildlife
dc.titleInternational clones of extended-spectrum β-lactamase (CTX-M)-producing Escherichia coli in peri-urban wild animals, Brazil
dc.typeArtigo de periódico
local.citation.epage1815
local.citation.issue5
local.citation.spage1804
local.citation.volume67
local.description.resumoCTX-M-type extended-spectrum β-lactamase (ESBL)-producing Escherichia coli clones have been increasingly reported worldwide. In this regard, although discussions of transmission routes of these bacteria are in evidence, molecular data are lacking to elucidate the epidemiological impacts of ESBL producers in wild animals. In this study, we have screened 90 wild animals living in a surrounding area of São Paulo, the largest metropolitan city in South America, to monitor the presence of multidrug-resistant (MDR) Gram-negative bacteria. Using a genomic approach, we have analysed eight ceftriaxone-resistant E. coli. Resistome analyses revealed that all E. coli strains carried blaCTX-M-type genes, prevalent in human infections, besides other clinically relevant resistance genes to aminoglycosides, β-lactams, phenicols, tetracyclines, sulphonamides, trimethoprim, fosfomycin and quinolones. Additionally, E. coli strains belonged to international sequence types (STs) ST38, ST58, ST212, ST744, ST1158 and ST1251, and carried several virulence-associated genes. Our findings suggest spread and adaptation of international clones of CTX-M-producing E. coli beyond urban settings, including wildlife from shared environments.
local.identifier.orcidhttps://orcid.org/0000-0002-0210-8352
local.identifier.orcidhttps://orcid.org/0000-0002-4725-0125
local.identifier.orcidhttps://orcid.org/0000-0001-8223-1758
local.identifier.orcidhttps://orcid.org/0000-0003-3787-1988
local.identifier.orcidhttps://orcid.org/0000-0003-0161-5800
local.publisher.countryBrasil
local.publisher.departmentVET - DEPARTAMENTO DE CLÍNICA E CIRURGIA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/tbed.13558

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